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ketohexokinase

Summary

Gene Symbol

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25659

PubChem

25659

Alliance of Genome Resources

RGD:2966

Annotation

Keyword

ATP-binding
Alternative splicing
Carbohydrate metabolism
Direct protein sequencing
Kinase
Proteomics identification
Reference proteome

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A8I6G7X9
Q02974	Hepatic fructokinase
A6HAB0
A6HAA9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
fructose catabolic process	ISO
regulation of glycogen metabolic process	IBA ISO
fructose metabolic process	IBA IDA IEA ISO	8471037
response to zinc ion	IBA IDA	12721403
response to fructose	IBA IEP	18346472

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organic substance catabolic process [inference]

carbohydrate catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

carbohydrate phosphorylation

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organophosphate metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

fructose catabolic process

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

hexose catabolic process [inference]

fructose catabolic process

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

carbohydrate catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

carbohydrate phosphorylation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

fructose catabolic process

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

hexose catabolic process [inference]

fructose catabolic process

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

fructose catabolic process

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

hexose catabolic process [inference]

fructose catabolic process

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

carbohydrate catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

carbohydrate phosphorylation

cellular aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organophosphate metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

carbohydrate derivative metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organic substance catabolic process [inference]

carbohydrate catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

carbohydrate phosphorylation

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organophosphate metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to disaccharide [inference]

response to sucrose

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to inorganic substance [inference]

response to metal ion [inference]

response to zinc ion

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to disaccharide [inference]

response to sucrose

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of generation of precursor metabolites and energy [inference]

regulation of glycogen metabolic process

regulation of macromolecule metabolic process [inference]

regulation of polysaccharide metabolic process [inference]

regulation of glycogen metabolic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of polysaccharide metabolic process [inference]

regulation of glycogen metabolic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of generation of precursor metabolites and energy [inference]

regulation of glycogen metabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleus	ISO
cytosol	ISO
cytoplasm	IBA IEA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
ketohexokinase activity	IBA IDA IEA ISO TAS	8471037
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

carbohydrate kinase activity [inference]

ketohexokinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

ketohexokinase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Rhea

RHEA:18145

β-D-fructose + ATP

β-D-fructose 1-phosphate + H⁺ + ADP

Enzyme

2.7.1.3

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111680	essential fructosuria	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	39279	FB:FBgn0036160
Drosophila melanogaster	39280	FB:FBgn0036161
Drosophila melanogaster	40203	FB:FBgn0036941
Drosophila melanogaster	40204	FB:FBgn0036942
Callorhinchus milii	103184052		CALMI03264
Danio rerio	436909	ZFIN:ZDB-GENE-040718-381	DANRE12293
Ictalurus punctatus	108269966		ICTPU34991
Electrophorus electricus	113571086		ELEEL09348
Salmo salar	100306748		SALSA07078
Salmo trutta	115172940		SALTR71826