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sodium voltage-gated channel alpha subunit 5

Summary

Gene Symbol

Scn5a

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25665

PubChem

25665

Alliance of Genome Resources

RGD:3637

Annotation

Keyword

3D-structure
Alternative splicing
Calmodulin-binding
Cell junction
Cell membrane
Cytoplasm
Disulfide bond
Glycoprotein
Methylation
Phosphoprotein
Reference proteome
Repeat
Sodium channel
Transmembrane helix
Ubl conjugation
Voltage-gated channel

Proteins

Displaying 1 entry
UniProt	Protein Name
P15389	Sodium channel protein cardiac muscle subunit alpha Sodium channel protein type V subunit alpha Voltage-gated sodium channel subunit alpha Nav1.5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 41 in total

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GO Term	Evidence Code	PMID
brainstem development	IEP	22331407
membrane depolarization during Purkinje myocyte cell action potential	IEA ISO ISS
regulation of cardiac muscle cell contraction	IEA ISO ISS
response to organic cyclic compound	ISO
action potential	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell communication involved in cardiac conduction [inference]

AV node cell to bundle of His cell communication

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction [inference]

cardiac muscle contraction

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

odontogenesis [inference]

odontogenesis of dentin-containing tooth

anatomical structure development [inference]

cardiac chamber development [inference]

cardiac ventricle development

response to stimulus [inference]

response to inactivity [inference]

response to muscle inactivity [inference]

response to muscle inactivity involved in regulation of muscle adaptation [inference]

response to denervation involved in regulation of muscle adaptation

response to stimulus involved in regulation of muscle adaptation [inference]

response to muscle inactivity involved in regulation of muscle adaptation [inference]

response to denervation involved in regulation of muscle adaptation

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound

response to calcium ion [inference]

cellular response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

response to oxygen-containing compound [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

response to salt [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

sodium ion transmembrane transport

sodium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of sodium ion transmembrane transport

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of sodium ion transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of sodium ion transmembrane transport

positive regulation of monoatomic ion transport [inference]

positive regulation of sodium ion transport

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of sodium ion transport

positive regulation of biological process [inference]

positive regulation of action potential

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of sodium ion transport

positive regulation of multicellular organismal process [inference]

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

regulation of cellular process [inference]

regulation of membrane depolarization [inference]

regulation of actin filament-based process [inference]

regulation of actin filament-based movement [inference]

regulation of cardiac muscle cell contraction

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of sodium ion transmembrane transport

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle cell contraction

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate

positive regulation of heart contraction [inference]

positive regulation of heart rate

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle cell contraction

cardiac conduction [inference]

regulation of heart rate by cardiac conduction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

positive regulation of multicellular organismal process [inference]

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

regulation of membrane repolarization [inference]

regulation of cardiac muscle cell membrane repolarization [inference]

regulation of action potential [inference]

positive regulation of action potential

regulation of biological quality [inference]

regulation of heart rate

regulation of membrane potential [inference]

action potential

neuronal action potential

cardiac muscle cell action potential [inference]

cardiac muscle cell action potential involved in contraction

regulation of membrane depolarization [inference]

membrane depolarization

membrane depolarization during action potential

membrane depolarization during cardiac muscle cell action potential

regulation of membrane repolarization [inference]

regulation of cardiac muscle cell membrane repolarization [inference]

regulation of action potential [inference]

positive regulation of action potential

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GO Term	Evidence Code	PMID
membrane	ISO ISS
sodium channel complex	ISO
sarcolemma	ISO
lateral plasma membrane	ISO
T-tubule	IDA IEA ISO	15579534

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated sodium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex

voltage-gated sodium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex

voltage-gated sodium channel complex

cellular anatomical entity [inference]

membrane

plasma membrane

sarcolemma

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

cell-cell contact zone [inference]

intercalated disc

T-tubule

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

nucleolus

perinuclear region of cytoplasm

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GO Term	Evidence Code	PMID
protein binding	IPI	11238277 19661460
fibroblast growth factor binding	IEA IPI ISO	12401812
ankyrin binding	IDA IEA IPI ISO	15579534
calmodulin binding	IEA ISO
enzyme binding	ISO

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

binding [inference]

protein binding

calmodulin binding

cytoskeletal protein binding [inference]

ankyrin binding

growth factor binding [inference]

fibroblast growth factor binding

enzyme binding

kinase binding [inference]

protein kinase binding

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

nitric-oxide synthase binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

sodium channel protein type 5 subunit alpha

Functional Category

M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
monoatomic ion channel activity
monoatomic ion transport
neuronal action potential
regulation of atrial cardiac muscle cell membrane depolarization
regulation of heart rate
sodium channel activity
sodium ion transmembrane transport
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
voltage-gated sodium channel activity

Displaying **all 7** entries
InterPro
Ion transport domain
Sodium ion transport-associated domain
Voltage gated sodium channel, alpha-5 subunit
Voltage-dependent channel domain superfamily
Voltage-gated Na+ ion channel, cytoplasmic domain
Voltage-gated cation channel calcium and sodium
Voltage-gated sodium channel alpha subunit, inactivation gate

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
T-tubule	PMID:15579534
intercalated disc	PMID:15579534 PMID:19661460

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0050431	arrhythmogenic right ventricular cardiomyopathy	Alliance of Genome Resources
DOID:0050650	familial atrial fibrillation	Alliance of Genome Resources
DOID:0060170	generalized epilepsy with febrile seizures plus	Alliance of Genome Resources
DOID:0080422	Dravet syndrome	Alliance of Genome Resources
DOID:0110218	Brugada syndrome 1	Alliance of Genome Resources
DOID:0110433	dilated cardiomyopathy 1E	Alliance of Genome Resources
DOID:0110646	long QT syndrome 3	Alliance of Genome Resources
DOID:0111074	progressive familial heart block type IA	Alliance of Genome Resources
DOID:0111294	generalized epilepsy with febrile seizures plus 2	Alliance of Genome Resources
DOID:13884	sick sinus syndrome	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	6331		HGNC:10593	HUMAN69247
Mus musculus	20271	10090_1:002e12	MGI:98251	MOUSE64002
Drosophila melanogaster	32619		FB:FBgn0285944
Bos taurus	282061			BOVIN17269
Canis lupus familiaris	403497			CANLF08960
Danio rerio	566868		ZFIN:ZDB-GENE-060908-3
Macaca mulatta	695085			MACMU29137
Pan troglodytes	747523			PANTR30801
Danio rerio	795688		ZFIN:ZDB-GENE-060908-2
Saccharomyces cerevisiae S288C	853131		SGD:S000003449

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements