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Guidelines

MIRAGE

WD repeat domain 72

Summary

Gene Symbol

WDR72

Organism

Homo sapiens (human)

External Links

NCBI Gene

256764

PubChem

256764

Alliance of Genome Resources

HGNC:26790

Annotation

Keyword

Amelogenesis imperfecta
Biomineralization
Cytoplasmic vesicle
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
WD repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3MJ13
A0A087WTC3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
regulation of pH	IEA
endocytosis	IEA
tubulin complex assembly	IEA
gene expression	IEA
vesicle organization	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

microtubule polymerization or depolymerization [inference]

microtubule polymerization

signal transduction [inference]

intracellular signal transduction [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

vesicle-mediated transport [inference]

endocytosis

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

ameloblast differentiation

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein import

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

microtubule polymerization or depolymerization [inference]

microtubule polymerization

vesicle organization

cellular component disassembly [inference]

extracellular matrix disassembly

cellular component assembly [inference]

protein-containing complex assembly [inference]

tubulin complex assembly

protein polymerization [inference]

microtubule polymerization

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

ruffle organization

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

tubulin complex assembly

protein polymerization [inference]

microtubule polymerization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

supramolecular fiber organization [inference]

microtubule polymerization

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

tooth mineralization [inference]

enamel mineralization

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

ameloblast differentiation

homeostatic process [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

regulation of pH

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein import

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

organic substance transport [inference]

protein transport [inference]

protein import

nitrogen compound transport [inference]

protein transport [inference]

protein import

import into cell [inference]

endocytosis

establishment of protein localization [inference]

protein transport [inference]

protein import

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein import

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of pH

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleus	IEA
cytoplasm	IDA	20938048
cytoplasm	IBA
endosome	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

WD repeat-containing protein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
InterPro
WD repeat-containing protein 7/72
WD40 repeat, conserved site
WD40 repeat
WD40-repeat-containing domain superfamily
WD40/YVTN repeat-like-containing domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110061	amelogenesis imperfecta hypomaturation type 2A3	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 55 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	256764	Xenbase:XB-GENE-1012344
Rattus norvegicus	300834		RATNO40918
Pan troglodytes	453451		PANTR10366
Canis lupus familiaris	487562		CANLF12533
Bos taurus	525892		BOVIN01314
Mus musculus	546144		MOUSE64201
Macaca mulatta	697128		MACMU40314
Monodelphis domestica	100031482		MONDO04753
Sus scrofa	100153251		PIGXX14279
Oryctolagus cuniculus	100353113		RABIT06043

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Last updated: December 8, 2025