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F-box protein 7

Summary

Gene Symbol

FBXO7

Organism

Homo sapiens (human)

External Links

NCBI Gene

25793

PubChem

25793

Alliance of Genome Resources

HGNC:13586

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Disease variant
Methylation
Mitochondrion
Neurodegeneration
Nucleus
Parkinson disease
Parkinsonism
Reference proteome
Ubl conjugation pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y3I1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
autophagy of mitochondrion	IMP	23933751
ubiquitin-dependent protein catabolic process	IDA	25029497
protein targeting to mitochondrion	IMP	23933751
regulation of neuron projection development	IMP	25029497
protein ubiquitination	IDA	16510124

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

protein K48-linked ubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

catabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

autophagy of mitochondrion

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

autophagy of mitochondrion

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

protein K48-linked ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

protein K48-linked ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

protein K48-linked ubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

protein K48-linked ubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

autophagy of mitochondrion

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

process utilizing autophagic mechanism [inference]

autophagy [inference]

autophagy of mitochondrion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

autophagy of mitochondrion

organelle disassembly [inference]

autophagy of mitochondrion

cellular component disassembly [inference]

organelle disassembly [inference]

autophagy of mitochondrion

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of localization [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

negative regulation of lymphocyte differentiation

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

negative regulation of lymphocyte differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

regulation of mitophagy [inference]

positive regulation of mitophagy

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy [inference]

positive regulation of mitophagy

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

regulation of mitophagy [inference]

positive regulation of mitophagy

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy [inference]

positive regulation of mitophagy

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of locomotion

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

negative regulation of lymphocyte differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

negative regulation of lymphocyte differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

regulation of mitophagy [inference]

positive regulation of mitophagy

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy [inference]

positive regulation of mitophagy

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

negative regulation of lymphocyte differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

negative regulation of lymphocyte differentiation

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

regulation of mitochondrion organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy [inference]

positive regulation of mitophagy

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of autophagy of mitochondrion

positive regulation of mitophagy

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle phase transition [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle G1/S phase transition [inference]

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

negative regulation of lymphocyte differentiation

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

negative regulation of lymphocyte differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation

regulation of biological quality [inference]

regulation of protein stability

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GO Term	Evidence Code	PMID
ubiquitin ligase complex	IDA	23933751
nucleus	IDA	16510124 18495667 21347293 21378169 23656991 25029497 26310625 36646384
nucleoplasm	IDA
cytoplasm	IDA	16510124 21347293 21378169 23656991 25029497
mitochondrion	IDA	23933751 26310625

GO Hierarchy

cellular component

protein-containing complex

intracellular protein-containing complex [inference]

ubiquitin ligase complex

cullin-RING ubiquitin ligase complex [inference]

SCF ubiquitin ligase complex

catalytic complex [inference]

transferase complex [inference]

ubiquitin ligase complex

cullin-RING ubiquitin ligase complex [inference]

SCF ubiquitin ligase complex

cellular anatomical entity [inference]

intracellular anatomical structure [inference]

inclusion body [inference]

glial cytoplasmic inclusion

Lewy body [inference]

classical Lewy body

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

Lewy neurite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

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GO Term	Evidence Code	PMID
ubiquitin-protein transferase activity	TAS	10531035
protein binding	IPI	15145941 16278047 21378169 22632967 23933751 25029497 25416956 25910212 26496610 27705803 28514442 31515488 32814053 33961781
protein kinase binding	IBA
protein kinase binding	IPI	18495667
ubiquitin protein ligase binding	IPI	16510124

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

ubiquitin-like protein binding [inference]

ubiquitin binding

protein dimerization activity [inference]

protein heterodimerization activity

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

enzyme-substrate adaptor activity [inference]

ubiquitin ligase-substrate adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

F-box only protein

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
positive regulation of autophagy of mitochondrion
protein kinase binding

Displaying **all 2** entries
InterPro
F-box domain
F-box-like domain superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060372	Parkinson's disease 15	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	25793	Xenbase:XB-GENE-994354
Mus musculus	69754		MOUSE00150
Rattus norvegicus	366854		RATNO37665
Pan troglodytes	470266		PANTR26420
Canis lupus familiaris	474522		CANLF01681
Bos taurus	508235		BOVIN29891
Danio rerio	558097		DANRE33400
Macaca mulatta	717317		MACMU02342
Monodelphis domestica	100016137		MONDO33158
Ornithorhynchus anatinus	100077846		ORNAN05712

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements