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polypeptide N-acetylgalactosaminyltransferase 2

Summary

Gene Symbol

GALNT2

Aliases

GalNAc-T2
polypeptide GalNAc transferase 2

Organism

Homo sapiens (human)

External Links

NCBI Gene

2590

GGDB ID

gg088

HGNC

4124

mRNA

NM_004481

map

1q41-q42

Protein

NP_004472

OMIM

602274

KEGG Gene ID

hsa:2590

PubChem

2590

Alliance of Genome Resources

HGNC:4124

Annotation

Keyword

3D-structure
Alternative splicing
Congenital disorder of glycosylation
Direct protein sequencing
Disease variant
Disulfide bond
Glycosyltransferase
Golgi apparatus
Lectin
Manganese
Metal-binding
Phosphoprotein
Proteoglycan
Reference proteome
Secreted
Signal
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A1L7NY50	Protein-UDP acetylgalactosaminyltransferase
B7Z6K2	Protein-UDP acetylgalactosaminyltransferase
Q10471	Polypeptide GalNAc transferase 2 Protein-UDP acetylgalactosaminyltransferase 2 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein O-linked glycosylation	IBA IDA	16434399 19460755
protein maturation	IDA	12438318
protein O-linked glycosylation via threonine	IDA	12438318 18562306 9295285
O-glycan processing	IDA TAS	18562306
protein O-linked glycosylation via serine	IDA	12438318 9295285

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine

protein maturation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine

protein maturation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine

protein maturation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine

protein maturation

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GO Term	Evidence Code	PMID
extracellular region	IEA
endoplasmic reticulum membrane	TAS
membrane	HDA	19946888
Golgi apparatus	IBA IDA	12506059 9852147
Golgi cisterna membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi stack

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

perinuclear region of cytoplasm

Displaying **all 4** entries
GO Term	Evidence Code	PMID
manganese ion binding	IDA	16434399 9295285
carbohydrate binding	IEA
protein binding	IPI	21699783 25416956 32296183
polypeptide N-acetylgalactosaminyltransferase activity	IBA IDA TAS	12438318 16434399 18562306 19460755 9295285

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylgalactosaminyltransferase activity [inference]

polypeptide N-acetylgalactosaminyltransferase activity

hexosyltransferase activity [inference]

acetylgalactosaminyltransferase activity [inference]

polypeptide N-acetylgalactosaminyltransferase activity

catalytic activity, acting on a protein [inference]

polypeptide N-acetylgalactosaminyltransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000143641

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg088

Gene Symbol

GALNT2

Orthologous Gene

Displaying **all 4** entries
Species	Protein	mRNA
Rattus norvegicus	XP_238057	XM_238057
Drosophila melanogaster	NP_995625	NM_205903
Caenorhabditis elegans	NP_507850	NM_075449
Mus musculus	NP_644678	NM_139272

KEGG BRITE Database

Orthology

K00710

Name

polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]

References

9295285

Rhea

RHEA:23956

UDP-N-acetyl-α-D-galactosamine

H⁺ + UDP

Enzyme

2.4.1.41

PMID

RHEA:52424

UDP-N-acetyl-α-D-galactosamine

H⁺ + UDP

Enzyme

2.4.1.41

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 47 in total

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DO ID	Disease Name	Source
DOID:3571	liver cancer	DisGeNET
DOID:0050571	congenital disorder of glycosylation type II	Alliance of Genome Resources
DOID:0050589	inflammatory bowel disease	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0060192	Crohn's colitis	DisGeNET
DOID:0080041	hypochondroplasia	DisGeNET
DOID:0110892	inflammatory bowel disease 1	DisGeNET
DOID:0111368	cholesterol-ester transfer protein deficiency	DisGeNET
DOID:0111369	hyperalphalipoproteinemia 1	DisGeNET
DOID:10534	stomach cancer	DisGeNET DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 40 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000020	Urinary incontinence
HP:0000248	Brachycephaly
HP:0000252	Microcephaly
HP:0000276	Long face
HP:0000316	Hypertelorism
HP:0000322	Short philtrum
HP:0000348	High forehead
HP:0000358	Posteriorly rotated ears
HP:0000369	Low-set ears

Displaying 1 entry
Disease ID	Disease Name
OMIM:618885	congenital disorder of glycosylation, type iit

PubChem Disease

MedGen Diseases

Congenital disorder of glycosylation, type iit

OMIM Phenotypes

CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIt; CDG2T

KEGG Diseases

Congenital disorders of glycosylation type II

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **31 - 40** of 73 in total

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Species	Gene ID	Orthologous MAtrix
Panthera leo	122202080	PANLE03622
Balaenoptera musculus	118882435	BALMU15754
Loxodonta africana	100659710	LOXAF13747
Equus caballus	100065695	HORSE18142
Bos taurus	616218	BOVIN22242
Capra hircus	102186274	CAPHI18870
Ovis aries	101102616	SHEEP12728
Oryctolagus cuniculus	100338673	RABIT05642
Dipodomys ordii	105984526	DIPOR05637
Cricetulus griseus	100767525	CRIGR02546

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements