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zinc finger DHHC-type palmitoyltransferase 5

Summary

Gene Symbol

ZDHHC5

Organism

Homo sapiens (human)

External Links

NCBI Gene

25921

PubChem

25921

Alliance of Genome Resources

HGNC:18472

Annotation

Keyword

Acyltransferase
Alternative splicing
Cell membrane
Innate immunity
Lipid transport
Methylation
Palmitate
Phosphoprotein
Reference proteome
Synapse
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9C0B5	Zinc finger DHHC domain-containing protein 5 Zinc finger protein 375

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
lipid transport	IEA
protein palmitoylation	IDA	22325201 23034182
innate immune response	IEA
positive regulation of pattern recognition receptor signaling pathway	IMP	31649195
positive regulation of pattern recognition receptor signaling pathway	IBA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

protein palmitoylation

protein acylation [inference]

protein palmitoylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

protein palmitoylation

protein acylation [inference]

protein palmitoylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

protein palmitoylation

protein acylation [inference]

protein palmitoylation

macromolecule modification [inference]

protein modification process [inference]

protein lipidation [inference]

protein palmitoylation

protein acylation [inference]

protein palmitoylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

protein palmitoylation

protein acylation [inference]

protein palmitoylation

cellular process [inference]

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

lipid transport

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of pattern recognition receptor signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of pattern recognition receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to phagocytic vesicle

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to phagocytic vesicle [inference]

positive regulation of protein localization to phagocytic vesicle

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of pyroptosis

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to phagocytic vesicle

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of pattern recognition receptor signaling pathway

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of pattern recognition receptor signaling pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of pattern recognition receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of pattern recognition receptor signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of pattern recognition receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of pattern recognition receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway

regulation of programmed cell death [inference]

positive regulation of programmed cell death [inference]

positive regulation of pyroptosis

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

regulation of NLRP3 inflammasome complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of pyroptosis

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to phagocytic vesicle

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

regulation of NLRP3 inflammasome complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to phagocytic vesicle

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to phagocytic vesicle [inference]

positive regulation of protein localization to phagocytic vesicle

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of biological quality [inference]

regulation of postsynaptic membrane neurotransmitter receptor levels

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
nucleoplasm	IDA
plasma membrane	IDA	16647879 31402609 31649195
plasma membrane	IBA
membrane	HDA	19946888

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

membrane

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

cell junction [inference]

synapse [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

postsynaptic specialization, intracellular component

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

intracellular non-membrane-bounded organelle [inference]

postsynaptic specialization, intracellular component

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	31402609 32353859 33060197 33845483 33961781 34117209 35115020 36217030
palmitoyltransferase activity	IDA	22325201 23034182 30605677
palmitoyltransferase activity	IBA
protein-cysteine S-palmitoyltransferase activity	IDA	29185452 31649195 34293401 38530158 38599239

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

palmitoyltransferase activity

protein-cysteine S-palmitoyltransferase activity

S-acyltransferase activity [inference]

protein-cysteine S-acyltransferase activity [inference]

protein-cysteine S-palmitoyltransferase activity

catalytic activity, acting on a protein [inference]

protein-cysteine S-acyltransferase activity [inference]

protein-cysteine S-palmitoyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

palmitoyltransferase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
palmitoyltransferase activity
protein targeting to membrane
protein-cysteine S-palmitoyltransferase activity
transferase activity

Displaying 1 entry
InterPro
Palmitoyltransferase, DHHC domain

Ortholog

Displaying entries **1 - 10** of 69 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus laevis	25921	Xenbase:XB-GENE-6489088
Drosophila melanogaster	27801	FB:FBgn0085478
Drosophila melanogaster	29801	FB:FBgn0085478
Mus musculus	228136	ZFIN:ZDB-GENE-090312-92	MOUSE34743
Rattus norvegicus	362156		RATNO26645
Pan troglodytes	451199		PANTR02939
Bos taurus	533250		BOVIN07699
Monodelphis domestica	100022895		MONDO26513
Equus caballus	100066506		HORSE05704
Pongo abelii	100173176		PONAB03672

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OrthoDB (Group)

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Acknowledgements