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GDP-fucose protein O-fucosyltransferase 2

Summary

Gene Symbol

pad-2

Organism

Caenorhabditis elegans

External Links

NCBI Gene

259529

KEGG Gene ID

cel:CELE_K10G9.3

PubChem

259529

Alliance of Genome Resources

WB:WBGene00010757

Annotation

Keyword

3D-structure
Disulfide bond
Endoplasmic reticulum
Fucose metabolism
Glycoprotein
Glycosyltransferase
Golgi apparatus
Proteomics identification
Reference proteome
Signal
Transferase

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8WR51	Patterning defective protein 2 Peptide-O-fucosyltransferase 2
G1K0W1	Peptide-O-fucosyltransferase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein O-linked fucosylation	IDA IEA ISS	26854667
protein glycosylation	IEA
fucose metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation [inference]

protein O-linked fucosylation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation [inference]

protein O-linked fucosylation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

glycosylation [inference]

fucosylation [inference]

protein O-linked fucosylation

macromolecule glycosylation [inference]

protein glycosylation

protein O-linked glycosylation [inference]

protein O-linked fucosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation [inference]

protein O-linked fucosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation [inference]

protein O-linked fucosylation

macromolecule glycosylation [inference]

protein glycosylation

protein O-linked glycosylation [inference]

protein O-linked fucosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation [inference]

protein O-linked fucosylation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
Golgi apparatus	IEA
cellular_component	ND
endoplasmic reticulum	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
peptide-O-fucosyltransferase activity	IBA IDA IEA ISS	26854667
transferase activity	IEA
glycosyltransferase activity	IEA
molecular_function	ND

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

glycosyltransferase activity

hexosyltransferase activity [inference]

fucosyltransferase activity [inference]

peptide-O-fucosyltransferase activity

catalytic activity, acting on a protein [inference]

peptide-O-fucosyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
fucose metabolic process
peptide-O-fucosyltransferase activity
protein O-linked fucosylation
transferase activity

Displaying **all 2** entries
InterPro
GDP-fucose protein O-fucosyltransferase 2-like
GDP-fucose protein O-fucosyltransferase

KEGG BRITE Database

Orthology

K03691

Name

peptide-O-fucosyltransferase [EC:2.4.1.221]

References

11524432

Rhea

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:14250	Down syndrome	Alliance of Genome Resources

Ortholog

Displaying **all 10** entries
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	23275		HGNC:14683
Drosophila melanogaster	31098		FB:FBgn0027791
Mus musculus	80294		MGI:1916863
Rattus norvegicus	309686		RGD:1307334
Danio rerio	777668		ZFIN:ZDB-GENE-030131-3595
Xenopus tropicalis	779585		Xenbase:XB-GENE-1018927
Brugia malayi	6102755	6279_0:002660
Loa loa	9940188	7209_0:000b63
Necator americanus	25357430	51031_0:000e69
Strongyloides ratti	36377937	34506_0:001b80

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024