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dynein axonemal heavy chain 1

Summary

Gene Symbol

DNAH1

Organism

Homo sapiens (human)

External Links

NCBI Gene

25981

PubChem

25981

Alliance of Genome Resources

HGNC:2940

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cilium
Coiled coil
Cytoskeleton
Disease variant
Dynein
Flagellum
Kartagener syndrome
Microtubule
Motor protein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A140VJI6
Q9P2D7	Axonemal beta dynein heavy chain 1 Ciliary dynein heavy chain 1 Heat shock regulated protein 1 hDHC7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
epithelial cilium movement involved in extracellular fluid movement	IEA
sperm axoneme assembly	IMP	24360805
flagellated sperm motility	IMP	24360805 27798045
flagellated sperm motility	IBA
inner dynein arm assembly	IDA	24360805

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

microtubule bundle formation [inference]

axoneme assembly [inference]

sperm axoneme assembly

microtubule-based movement [inference]

cilium movement [inference]

epithelial cilium movement involved in extracellular fluid movement

cilium movement involved in cell motility [inference]

flagellated sperm motility

cellular process involved in reproduction in multicellular organism [inference]

sperm axoneme assembly

cell motility [inference]

cilium or flagellum-dependent cell motility [inference]

cilium-dependent cell motility

flagellated sperm motility

sperm motility [inference]

flagellated sperm motility

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

microtubule bundle formation [inference]

axoneme assembly [inference]

sperm axoneme assembly

cellular component assembly [inference]

axoneme assembly [inference]

sperm axoneme assembly

protein-containing complex assembly [inference]

axonemal dynein complex assembly [inference]

inner dynein arm assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

axonemal dynein complex assembly [inference]

inner dynein arm assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

sperm axoneme assembly

cellular process involved in reproduction in multicellular organism [inference]

sperm axoneme assembly

sperm motility [inference]

flagellated sperm motility

developmental process [inference]

developmental process involved in reproduction [inference]

sperm axoneme assembly

localization [inference]

establishment of localization [inference]

transport [inference]

extracellular transport [inference]

epithelial cilium movement involved in extracellular fluid movement

microtubule-based transport [inference]

epithelial cilium movement involved in extracellular fluid movement

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GO Term	Evidence Code	PMID
extracellular region	IEA
axonemal dynein complex	NAS	9373155
microtubule	IEA
axoneme	IMP	24360805
dynein complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex [inference]

dynein complex

axonemal dynein complex

inner dynein arm

catalytic complex [inference]

dynein complex

axonemal dynein complex

inner dynein arm

cellular anatomical entity [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium [inference]

9+2 motile cilium [inference]

sperm flagellum

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium [inference]

9+2 motile cilium [inference]

sperm flagellum

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying **all 5** entries
GO Term	Evidence Code	PMID
microtubule motor activity	NAS	9373155
ATP binding	IEA
minus-end-directed microtubule motor activity	IBA
dynein intermediate chain binding	IBA
dynein light intermediate chain binding	IBA

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microtubule motor activity

minus-end-directed microtubule motor activity

binding [inference]

protein binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microtubule motor activity

minus-end-directed microtubule motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dynein

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
dynein intermediate chain binding
dynein light intermediate chain binding
microtubule-based movement
minus-end-directed microtubule motor activity

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InterPro
Dynein heavy chain AAA lid domain superfamily
Dynein heavy chain AAA lid domain
Dynein heavy chain region D6 P-loop domain
Dynein heavy chain, AAA 5 extension domain
Dynein heavy chain, AAA module D4
Dynein heavy chain, AAA1 domain, small subdomain
Dynein heavy chain, ATP-binding dynein motor region
Dynein heavy chain, coiled coil stalk
Dynein heavy chain, domain 2, N-terminal
Dynein heavy chain, hydrolytic ATP-binding dynein motor region

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0070165	spermatogenic failure 18	Alliance of Genome Resources
DOID:0080266	primary ciliary dyskinesia 37	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 65 in total

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Species	Gene ID	Orthologous MAtrix
Chinchilla lanigera	102015430	CHILA08775
Macaca fascicularis	102117317	MACFA27295
Capra hircus	102173136	CAPHI14630
Latimeria chalumnae	102364160	LATCH19660
Myotis lucifugus	102421278	MYOLU06298
Neolamprologus brichardi	102783657	NEOBR04662
Callorhinchus milii	103189502	CALMI41631
Chlorocebus sabaeus	103227730	CHLSB10423
Ursus maritimus	103675071	URSMA11871
Nannospalax galili	103749041	NANGA09242

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Annotation

OrthoDB (Group)

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Acknowledgements