GlyCosmos Portal

Annotation

Keyword

ATP-binding
Alternative splicing
Cataract
Cobalt
FAD
Kinase
Lyase
Magnesium
Manganese
Metal-binding
Multifunctional enzyme
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A140VJH7	Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)
Q3LXA3	Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
negative regulation of MDA-5 signaling pathway	IDA	17600090
carbohydrate metabolic process	IDA	16289032 4688871
regulation of innate immune response	IDA	16289032
glycerol catabolic process	IBA
fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate	IEA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

carbohydrate phosphorylation

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organophosphate metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

primary metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

alditol metabolic process [inference]

glycerol metabolic process [inference]

glycerol catabolic process

alditol catabolic process [inference]

glycerol catabolic process

carbohydrate phosphorylation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process [inference]

glycerol catabolic process

alditol catabolic process [inference]

glycerol catabolic process

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organic substance metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

alditol metabolic process [inference]

glycerol metabolic process [inference]

glycerol catabolic process

alditol catabolic process [inference]

glycerol catabolic process

carbohydrate phosphorylation

cellular aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organophosphate metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

carbohydrate derivative metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process [inference]

glycerol catabolic process

alditol catabolic process [inference]

glycerol catabolic process

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

carbohydrate phosphorylation

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organophosphate metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of immune response [inference]

regulation of innate immune response

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of MDA-5 signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of MDA-5 signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of MDA-5 signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of MDA-5 signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of response to external stimulus [inference]

regulation of innate immune response

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of MDA-5 signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of immune response [inference]

regulation of innate immune response

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of MDA-5 signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of innate immune response

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of MDA-5 signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of MDA-5 signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleus	HDA	21630459
cytosol	IBA TAS
extracellular exosome	HDA	19056867 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
triokinase activity	IDA	32004446 4688871
glycerone kinase activity	IBA IDA	16289032 32004446 4688871
metal ion binding	IEA
ATP binding	IEA
protein binding	IPI	17600090 25416956

GO Hierarchy

molecular function

catalytic activity [inference]

cyclase activity [inference]

FAD-AMP lyase (cyclizing) activity

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

phosphotransferase activity, alcohol group as acceptor [inference]

lyase activity [inference]

phosphorus-oxygen lyase activity [inference]

FAD-AMP lyase (cyclizing) activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00863

Name

triose/dihydroxyacetone kinase / FAD-AMP lyase (cyclizing) [EC:2.7.1.28 2.7.1.29 4.6.1.15]

References

Rhea

RHEA:13941

D-glyceraldehyde + ATP

H⁺ + ADP + D-glyceraldehyde 3-phosphate

Enzyme

2.7.1.28

PMID

RHEA:13729

FAD

H⁺ + AMP + riboflavin cyclic-4',5'-phosphate

Enzyme

4.6.1.15

PMID

RHEA:15773

dihydroxyacetone + ATP

H⁺ + ADP + dihydroxyacetone phosphate

Enzyme

2.7.1.29

PMID

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:1837	diabetic ketoacidosis	DisGeNET
DOID:409	liver disease	DisGeNET
DOID:83	cataract	DisGeNET
DOID:9351	diabetes mellitus	DisGeNET DisGeNET
DOID:9352	type 2 diabetes mellitus	DisGeNET DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 27 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000486	Strabismus
HP:0000501	Glaucoma
HP:0000512	Abnormal electroretinogram
HP:0000518	Cataract
HP:0000545	Myopia
HP:0000568	Microphthalmia
HP:0000639	Nystagmus
HP:0000750	Delayed speech and language development
HP:0001131	Corneal dystrophy

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:618805	triokinase and FMN cyclase deficiency syndrome
ORPHA:1369	Sengers syndrome

PubChem Disease

MedGen Diseases

Triokinase and FMN cyclase deficiency syndrome

OMIM Phenotypes

TRIOKINASE AND FMN CYCLASE DEFICIENCY SYNDROME; TKFCD

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006684
Gene Name: dihydroxyacetone kinase 2 homolog (S. cerevisiae)

Ortholog

Displaying entries **1 - 10** of 76 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	178730	WB:WBGene00020962
Latimeria chalumnae	102352724		LATCH19039
Danio rerio	793926	ZFIN:ZDB-GENE-060929-652	DANRE41267
Astyanax mexicanus	103037716		ASTMX05589
Ictalurus punctatus	108267727		ICTPU32845
Electrophorus electricus	113573484		ELEEL10329
Oreochromis niloticus	100692489		ORENI50253
Xenopus laevis	108715194	Xenbase:XB-GENE-17345590
Xenopus tropicalis	779584	Xenbase:XB-GENE-990423
Pseudonaja textilis	113449122		PSETE22912

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements