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signal induced proliferation associated 1 like 1

Summary

Gene Symbol

SIPA1L1

Organism

Homo sapiens (human)

External Links

NCBI Gene

26037

PubChem

26037

Alliance of Genome Resources

HGNC:20284

Annotation

Keyword

Alternative splicing
Coiled coil
Cytoskeleton
GTPase activation
Methylation
Phosphoprotein
Reference proteome
Synaptosome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
O43166	High-risk human papilloma viruses E6 oncoproteins targeted protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
activation of GTPase activity	ISS
regulation of dendritic spine morphogenesis	ISS
regulation of synaptic plasticity	ISS
regulation of axonogenesis	ISS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

actin filament-based process [inference]

actin cytoskeleton organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of synapse organization [inference]

regulation of postsynapse organization [inference]

regulation of dendritic spine morphogenesis

regulation of biological quality [inference]

regulation of synaptic plasticity

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity

positive regulation of GTPase activity [inference]

activation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

Displaying **all 5** entries
GO Term	Evidence Code	PMID
postsynaptic density	ISS
plasma membrane	IDA
dendritic spine	ISS
actin cytoskeleton	IDA
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

postsynaptic specialization [inference]

postsynaptic density

postsynapse [inference]

dendritic spine

Displaying **all 4** entries
GO Term	Evidence Code	PMID
GTPase activator activity	IBA
protein binding	IPI	15778465 21653829 22117215 36931259
ephrin receptor binding	IEA
molecular_function	ND

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

ephrin receptor binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

signal-induced proliferation-associated 1

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
regulation of small GTPase mediated signal transduction

Displaying **all 2** entries
InterPro
Rap/Ran-GAP domain
Rap/Ran-GAP superfamily

Ortholog

Displaying entries **1 - 10** of 90 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	179596		WB:WBGene00012100
Mus musculus	217692		MGI:2443679	MOUSE09428
Rattus norvegicus	246212		RGD:708497	RATNO35410
Xenopus laevis	446241		Xenbase:XB-GENE-866800
Pan troglodytes	453008	9598_0:003c92		PANTR09083
Canis lupus familiaris	480379			CANLF18051
Danio rerio	562521		ZFIN:ZDB-GENE-030131-9909	DANRE18627
Macaca mulatta	694485			MACMU41057
Bos taurus	787248			BOVIN01653
Monodelphis domestica	100019973			MONDO01661

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Supported by JST NBDC Grant Number JPMJND2204

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Last updated: December 9, 2024