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ELKS/RAB6-interacting/CAST family member 2

Summary

Gene Symbol

ERC2

Organism

Homo sapiens (human)

External Links

NCBI Gene

26059

PubChem

26059

Alliance of Genome Resources

HGNC:31922

Annotation

Keyword

Cell projection
Coiled coil
Cytoskeleton
Phosphoprotein
Proteomics identification
Reference proteome
Synapse

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O15083
H7C4G9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
synaptic vesicle priming	IEA
maintenance of presynaptic active zone structure	IBA
regulation of presynaptic cytosolic calcium ion concentration	IEA
regulation of calcium-dependent activation of synaptic vesicle fusion	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

synaptic vesicle priming

cell junction organization [inference]

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of presynaptic active zone structure

synapse organization [inference]

maintenance of synapse structure [inference]

maintenance of presynaptic active zone structure

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

synaptic vesicle priming

cellular component maintenance [inference]

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of presynaptic active zone structure

presynaptic active zone organization [inference]

maintenance of presynaptic active zone structure

exocytic process [inference]

synaptic vesicle priming

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of presynaptic cytosolic calcium ion concentration

neuron cellular homeostasis [inference]

regulation of presynaptic cytosolic calcium ion concentration

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of presynaptic cytosolic calcium ion concentration

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of presynaptic cytosolic calcium ion concentration

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of presynaptic cytosolic calcium ion concentration

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of presynaptic cytosolic calcium ion concentration

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of presynaptic cytosolic calcium ion concentration

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of vesicle-mediated transport [inference]

regulation of vesicle fusion [inference]

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

regulation of calcium-dependent activation of synaptic vesicle fusion

regulation of cellular process [inference]

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of vesicle fusion [inference]

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

regulation of calcium-dependent activation of synaptic vesicle fusion

regulation of synaptic vesicle membrane organization [inference]

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

regulation of calcium-dependent activation of synaptic vesicle fusion

regulation of vesicle-mediated transport [inference]

regulation of vesicle fusion [inference]

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

regulation of calcium-dependent activation of synaptic vesicle fusion

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cytoskeleton	IEA
growth cone	ISS
presynaptic membrane	ISS
presynaptic active zone	TAS	15217342
presynaptic active zone cytoplasmic component	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm [inference]

cell cortex [inference]

cell cortex region [inference]

presynaptic active zone cytoplasmic component

cytoplasmic region [inference]

cell cortex region [inference]

presynaptic active zone cytoplasmic component

membrane [inference]

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

site of polarized growth [inference]

growth cone

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

presynaptic active zone

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	12923177 20195357
structural constituent of presynaptic active zone	IBA

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of synapse [inference]

structural constituent of presynaptic active zone

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ELKS/RAB6-interacting/CAST family member 1

Functional Category

J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
neuromuscular synaptic transmission
regulation of synaptic plasticity
structural constituent of presynaptic active zone

Displaying 1 entry
InterPro
Active zone protein ELKS

Ortholog

Displaying entries **1 - 10** of 69 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	23085	FB:FBgn0259246
Xenopus tropicalis	26059	Xenbase:XB-GENE-1013677
Drosophila melanogaster	111173	FB:FBgn0259246
Mus musculus	238988	Xenbase:XB-GENE-1013677	MOUSE12625
Rattus norvegicus	259269		RATNO11061
Pan troglodytes	460460		PANTR31377
Canis lupus familiaris	484720		CANLF07407
Bos taurus	537173		BOVIN17651
Macaca mulatta	705338		MACMU28776
Monodelphis domestica	100011705		MONDO30907