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MIRAGE

SERPINE1 mRNA binding protein 1

Summary

Gene Symbol

SERBP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

26135

PubChem

26135

Alliance of Genome Resources

HGNC:17860

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Direct protein sequencing
Isopeptide bond
Methylation
Nucleus
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome
Translation regulation
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8NC51	PAI1 RNA-binding protein 1 Plasminogen activator inhibitor 1 RNA-binding protein
Q5VU21

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
negative regulation of translation	IDA	36691768
PML body organization	IDA	28695742
regulation of mRNA stability	NAS	11001948
ribosome hibernation	IDA	36691768

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

nucleus organization [inference]

nuclear body organization [inference]

PML body organization

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation

ribosome hibernation

regulation of RNA stability [inference]

regulation of mRNA stability

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

negative regulation of protein metabolic process [inference]

negative regulation of translation

ribosome hibernation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation

ribosome hibernation

negative regulation of protein metabolic process [inference]

negative regulation of translation

ribosome hibernation

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation

ribosome hibernation

regulation of RNA stability [inference]

regulation of mRNA stability

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

regulation of cellular catabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

regulation of amide metabolic process [inference]

regulation of translation [inference]

negative regulation of translation

ribosome hibernation

negative regulation of amide metabolic process [inference]

negative regulation of translation

ribosome hibernation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation

ribosome hibernation

negative regulation of protein metabolic process [inference]

negative regulation of translation

ribosome hibernation

regulation of protein metabolic process [inference]

regulation of translation [inference]

negative regulation of translation

ribosome hibernation

negative regulation of protein metabolic process [inference]

negative regulation of translation

ribosome hibernation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation

ribosome hibernation

regulation of RNA stability [inference]

regulation of mRNA stability

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

negative regulation of protein metabolic process [inference]

negative regulation of translation

ribosome hibernation

regulation of protein metabolic process [inference]

regulation of translation [inference]

negative regulation of translation

ribosome hibernation

negative regulation of protein metabolic process [inference]

negative regulation of translation

ribosome hibernation

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

regulation of protein metabolic process [inference]

regulation of translation [inference]

negative regulation of translation

ribosome hibernation

negative regulation of protein metabolic process [inference]

negative regulation of translation

ribosome hibernation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

negative regulation of protein metabolic process [inference]

negative regulation of translation

ribosome hibernation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation

ribosome hibernation

negative regulation of protein metabolic process [inference]

negative regulation of translation

ribosome hibernation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation

ribosome hibernation

regulation of RNA stability [inference]

regulation of mRNA stability

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

regulation of cellular catabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

ribosome hibernation

regulation of biological quality [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

Displaying entries **1 - 5** of 8 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
nucleus	IDA	16879614
nucleus	IBA
cytoplasm	IDA	16879614
cytoplasm	IBA
cytosol	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 10 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
RNA binding	EXP	34631798
RNA binding	HDA	22658674 22681889
mRNA 3'-UTR binding	IDA	11001948
mRNA 3'-UTR binding	IBA
protein binding	IPI	12505151 16879614 24965446 32296183 32814053

GO Hierarchy

molecular function

binding [inference]

protein binding

ubiquitin-like protein binding [inference]

SUMO binding

cell adhesion molecule binding [inference]

cadherin binding

translation elongation factor binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

ribosome binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

mRNA binding [inference]

mRNA 3'-UTR binding

translation regulator activity [inference]

translation repressor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

plasminogen activator inhibitor 1 rna-binding protein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Hyaluronan/mRNA-binding protein
RNA binding protein HABP4/SERBP1-like

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025