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tubulin tyrosine ligase like 3

Summary

Gene Symbol

TTLL3

Organism

Homo sapiens (human)

External Links

NCBI Gene

26140

PubChem

26140

Alliance of Genome Resources

HGNC:24483

Annotation

Keyword

ATP-binding
Alternative splicing
Cytoplasm
Cytoskeleton
Flagellum
Ligase
Magnesium
Metal-binding
Microtubule
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9Y4R7	HOTTL Tubulin--tyrosine ligase-like protein 3
J3KQB2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein polyglycylation	IDA	19524510
protein modification process
cilium assembly	ISS
spermatogenesis	IBA
flagellated sperm motility	IBA ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein polyglycylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein polyglycylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein polyglycylation

macromolecule modification [inference]

protein modification process

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein polyglycylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein polyglycylation

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

microtubule bundle formation [inference]

axoneme assembly

microtubule-based movement [inference]

cilium movement

cilium movement involved in cell motility [inference]

flagellated sperm motility

cell motility [inference]

cilium or flagellum-dependent cell motility [inference]

cilium-dependent cell motility [inference]

flagellated sperm motility

sperm motility [inference]

flagellated sperm motility

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

microtubule bundle formation [inference]

axoneme assembly

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

axoneme assembly

organelle assembly [inference]

cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

sperm motility [inference]

flagellated sperm motility

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
microtubule	IEA
sperm flagellum	IBA ISS
microtubule cytoskeleton	IBA ISS
cytosol	TAS
axoneme	IBA ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

motile cilium [inference]

9+2 motile cilium [inference]

sperm flagellum

organelle [inference]

membrane-bounded organelle [inference]

motile cilium [inference]

9+2 motile cilium [inference]

sperm flagellum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein-glycine ligase activity, initiating	IBA ISS
protein-glycine ligase activity	IDA TAS	19524510
metal ion binding	IEA
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming carbon-nitrogen bonds [inference]

acid-amino acid ligase activity [inference]

protein-glycine ligase activity

protein-glycine ligase activity, initiating

catalytic activity, acting on a protein [inference]

protein-glycine ligase activity

protein-glycine ligase activity, initiating

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ligase

Functional Category

I: Lipid transport and metabolism
L: Replication, recombination and repair
P: Inorganic ion transport and metabolism

Displaying 1 entry
InterPro
Tubulin-tyrosine ligase/Tubulin polyglutamylase

Ortholog

Displaying entries **11 - 16** of 16 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Pan paniscus	100994357	9597_0:0010ff
Gorilla gorilla gorilla	101138545	9595_0:0010f0
Papio anubis	103881922			PAPAN24593
Aotus nancymaae	105730411			AOTNA17935
Mustela putorius furo	106003327			MUSPF19490
Pongo pygmaeus	129033233	9600_0:001024

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024