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integrator complex subunit 1

Summary

Gene Symbol

INTS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

26173

PubChem

26173

Alliance of Genome Resources

HGNC:24555

Annotation

Keyword

3D-structure
Acetylation
Disease variant
Intellectual disability
Nucleus
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8N201

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
embryo implantation	IEA
snRNA processing	IDA NAS	16239144
U2 snRNA 3'-end processing	IBA
negative regulation of apoptotic process	IEA
regulation of transcription elongation by RNA polymerase II	NAS	32697989

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

cellular process [inference]

cell population proliferation [inference]

inner cell mass cell proliferation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

reproductive process [inference]

embryo implantation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nuclear membrane	IEA
membrane	HDA	19946888
nucleoplasm	TAS
integrator complex	IBA IDA NAS	16239144 33548203
nucleus	NAS	32647223

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

integrator complex

cellular anatomical entity [inference]

nucleoplasm

membrane

organelle membrane [inference]

nuclear membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	28514442 33961781

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Integrator complex subunit

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism

Displaying 1 entry
Gene Ontology
U2 snRNA 3'-end processing

Displaying **all 3** entries
InterPro
Armadillo-type fold
Integrator complex subunit 1, RPB2-binding domain
Integrator complex subunit 1

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0070346	neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies	Alliance of Genome Resources
DOID:83	cataract	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 94 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	37840	FB:FBgn0034964
Mus musculus	68510	MGI:1915760	MOUSE46909
Caenorhabditis elegans	182280	WB:WBGene00015499
Rattus norvegicus	288514	RGD:1308908	RATNO05361
Danio rerio	562131	ZFIN:ZDB-GENE-030131-6523	DANRE31483
Macaca mulatta	711947		MACMU32586
Bos taurus	790146		BOVIN21055
Monodelphis domestica	100021404		MONDO28345
Ornithorhynchus anatinus	100083149		ORNAN15927
Taeniopygia guttata	100223218		TAEGU04921

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements