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cytochrome c oxidase subunit I

Summary

Gene Symbol

COX1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

26195

PubChem

26195

Alliance of Genome Resources

RGD:621871

Annotation

Keyword

Calcium
Copper
Heme
Magnesium
Mitochondrion inner membrane
Reference proteome
Respiratory chain
Sodium
Translocase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8HIC9
P05503	Cytochrome c oxidase polypeptide I

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
response to hypoxia	IEP	33310031
oxidative phosphorylation	IEA
mitochondrial electron transport, cytochrome c to oxygen
response to oxidative stress	IDA	17870132
aerobic respiration	IBA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration

oxidative phosphorylation

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

electron transport chain [inference]

respiratory electron transport chain

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration

oxidative phosphorylation

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

electron transport chain [inference]

respiratory electron transport chain

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

developmental process [inference]

anatomical structure development [inference]

cerebellum development

response to stimulus [inference]

response to stress [inference]

response to abiotic stimulus [inference]

response to electrical stimulus

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to chemical [inference]

response to inorganic substance [inference]

response to metal ion [inference]

response to copper ion

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasoconstriction

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

positive regulation of multicellular organismal process [inference]

positive regulation of vasoconstriction

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mitochondrion	ISO
mitochondrial inner membrane	ISO
mitochondrial membrane	ISO
respiratory chain complex IV	ISS
respiratory chain complex IV	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

respiratory chain complex [inference]

respiratory chain complex IV

catalytic complex [inference]

cytochrome complex [inference]

respiratory chain complex IV

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytochrome-c oxidase activity	ISS
cytochrome-c oxidase activity	ISO
cytochrome-c oxidase activity	IBA
heme binding	IEA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

electron transfer activity [inference]

cytochrome-c oxidase activity

oxidoreductase activity, acting on a heme group of donors [inference]

cytochrome-c oxidase activity

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

cytochrome-c oxidase activity

active monoatomic ion transmembrane transporter activity [inference]

cytochrome-c oxidase activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

cytochrome-c oxidase activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

oxidoreduction-driven active transmembrane transporter activity [inference]

cytochrome-c oxidase activity

active monoatomic ion transmembrane transporter activity [inference]

cytochrome-c oxidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026

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