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F-box protein 2

Summary

Gene Symbol

FBXO2

Aliases

FBX2
Fbg1
Fbs1
Nfb42

Organism

Homo sapiens (human)

External Links

NCBI Gene

26232

HGNC

13581

KEGG Gene ID

hsa:26232

PubChem

26232

Alliance of Genome Resources

HGNC:13581

Annotation

Keyword

Cytoplasm
Lectin
Membrane
Microsome
Reference proteome
Ubl conjugation pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UK22

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
ERAD pathway	IBA
protein ubiquitination	IEA ISS
regulation of protein ubiquitination	IEA
proteolysis		10531035
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

protein modification process

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

protein modification process

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

protein modification process

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

protein modification process

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of protein catabolic process [inference]

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination

regulation of protein catabolic process [inference]

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination

regulation of protein catabolic process [inference]

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination

regulation of protein catabolic process [inference]

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission [inference]

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission [inference]

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
glutamatergic synapse	IEA
endoplasmic reticulum	IEA
cytosol	ISS TAS
cytoplasm	IBA IDA	21378169
SCF ubiquitin ligase complex	IBA ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

ubiquitin ligase complex [inference]

cullin-RING ubiquitin ligase complex [inference]

SCF ubiquitin ligase complex

catalytic complex [inference]

transferase complex [inference]

ubiquitin ligase complex [inference]

cullin-RING ubiquitin ligase complex [inference]

SCF ubiquitin ligase complex

cellular anatomical entity [inference]

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of synaptic membrane [inference]

extrinsic component of postsynaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
ubiquitin-protein transferase activity		10531035
amyloid-beta binding	IEA
ubiquitin protein ligase activity	IBA
denatured protein binding	IEA
carbohydrate binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

binding [inference]

protein binding

denatured protein binding

carbohydrate binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K10099

Name

F-box protein 2

References

Disease

Disease Ontology

Displaying entries **1 - 10** of 24 in total

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DO ID	Disease Name	Source
DOID:0060891	Parkinson's disease 19A	DisGeNET
DOID:0060895	Parkinson's disease 4	DisGeNET
DOID:0060896	Parkinson's disease 23	DisGeNET
DOID:0080348	Alzheimer's disease 1	DisGeNET
DOID:0110035	Alzheimer's disease 2	DisGeNET
DOID:0110037	Alzheimer's disease 5	DisGeNET
DOID:0110038	Alzheimer's disease 6	DisGeNET
DOID:0110039	Alzheimer's disease 7	DisGeNET
DOID:0110041	Alzheimer's disease 8	DisGeNET
DOID:0110043	Alzheimer's disease 10	DisGeNET

Ortholog

Displaying entries **1 - 10** of 57 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	259498	WB:WBGene00007574
Callorhinchus milii	103181357		CALMI22548
Latimeria chalumnae	102345690		LATCH07718
Danio rerio	559776	ZFIN:ZDB-GENE-080204-124
Chrysemys picta bellii	101948036		CHRPI32737
Crocodylus porosus	109314272		CROPO20949
Meleagris gallopavo	100543541		MELGA07660
Ornithorhynchus anatinus	100090243		ORNAN21081
Callithrix jacchus	100394861		CALJA42149
Cercocebus atys	105580862		CERAT28949

GlyTouCan

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GlycoPOST

UniCarb-DR

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Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements