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F-box protein 2

Summary

Gene Symbol

FBXO2

Aliases

FBX2
Fbg1
Fbs1
Nfb42

Organism

Homo sapiens (human)

External Links

NCBI Gene

26232

HGNC

13581

KEGG Gene ID

hsa:26232

PubChem

26232

Alliance of Genome Resources

HGNC:13581

Annotation

Keyword

Cytoplasm
Lectin
Membrane
Microsome
Reference proteome
Ubl conjugation pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UK22

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
regulation of protein ubiquitination	IEA
proteolysis	TAS	10531035
regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IEA
protein modification process	TAS	10531035
negative regulation of cell population proliferation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

protein modification process

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

protein modification process

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

protein modification process

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

protein modification process

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of protein catabolic process [inference]

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination

regulation of protein catabolic process [inference]

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination

regulation of protein catabolic process [inference]

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination

regulation of protein catabolic process [inference]

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission [inference]

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission [inference]

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
SCF ubiquitin ligase complex	IBA ISS
extrinsic component of postsynaptic membrane	IEA
dendritic spine	IEA
endoplasmic reticulum	IEA
cytosol	ISS TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

ubiquitin ligase complex [inference]

cullin-RING ubiquitin ligase complex [inference]

SCF ubiquitin ligase complex

catalytic complex [inference]

transferase complex [inference]

ubiquitin ligase complex [inference]

cullin-RING ubiquitin ligase complex [inference]

SCF ubiquitin ligase complex

cellular anatomical entity [inference]

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of synaptic membrane [inference]

extrinsic component of postsynaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	25416956 27705803 32296183 33961781
denatured protein binding	IEA
ubiquitin protein ligase activity	IBA
amyloid-beta binding	IEA
carbohydrate binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

binding [inference]

protein binding

denatured protein binding

carbohydrate binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

F-box only protein

Functional Category

K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
glycoprotein catabolic process

Displaying **all 5** entries
InterPro
F-box associated (FBA) domain
F-box domain
F-box only protein
F-box-like domain superfamily
Galactose-binding-like domain superfamily

KEGG BRITE Database

Orthology

K10099

Name

F-box protein 2

References

Ortholog

Displaying entries **1 - 10** of 58 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	85273		RGD:621751	RATNO33643
Mus musculus	230904		MGI:2446216	MOUSE39685
Caenorhabditis elegans	259498		WB:WBGene00007574
Pan troglodytes	457951	9598_0:00062b		PANTR19933
Canis lupus familiaris	478231			CANLF07176
Bos taurus	512589			BOVIN08285
Danio rerio	559776		ZFIN:ZDB-GENE-080204-124
Macaca mulatta	722738			MACMU22931
Monodelphis domestica	100018509			MONDO23305
Equus caballus	100051196			HORSE28411

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements