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3-hydroxyisobutyryl-CoA hydrolase

Summary

Gene Symbol

HIBCH

Organism

Homo sapiens (human)

External Links

NCBI Gene

26275

HGNC

4908

KEGG Gene ID

hsa:26275

PubChem

26275

Alliance of Genome Resources

HGNC:4908

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Branched-chain amino acid catabolism
Disease variant
Hydrolase
Mitochondrion
Phosphoprotein
Reference proteome
Transit peptide

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6NVY1	3-hydroxyisobutyryl-coenzyme A hydrolase
A0A140VJL0	3-hydroxyisobutyryl-coenzyme A hydrolase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
branched-chain amino acid catabolic process	TAS
valine catabolic process	IBA IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrion	HTP IBA IDA	34800366
mitochondrial matrix	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying 1 entry
GO Term	Evidence Code	PMID
3-hydroxyisobutyryl-CoA hydrolase activity	EXP IBA IDA	8824301

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

thiolester hydrolase activity [inference]

CoA hydrolase activity [inference]

3-hydroxyisobutyryl-CoA hydrolase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

3-hydroxyisobutyryl-CoA hydrolase

Functional Category

G: Carbohydrate transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
3-hydroxyisobutyryl-CoA hydrolase activity
hydrolase activity
valine catabolic process

Displaying **all 3** entries
InterPro
ClpP/crotonase-like domain superfamily
Enoyl-CoA hydratase/isomerase domain
Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type

Human Protein Atlas

ENSG00000198130

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)