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VPS33B late endosome and lysosome associated

Summary

Gene Symbol

VPS33B

Organism

Homo sapiens (human)

External Links

NCBI Gene

26276

PubChem

26276

Alliance of Genome Resources

HGNC:12712

Annotation

Keyword

Acetylation
Alternative splicing
Cytoplasmic vesicle
Deafness
Disease variant
Endosome
Ichthyosis
Intrahepatic cholestasis
Lysosome
Membrane
Palmoplantar keratoderma
Phosphoprotein
Protein transport
Proteomics identification
Reference proteome

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A0S2Z577
B7Z1N4
F5H008
Q9H267

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
lysosome localization	IDA	15790593
endosome to lysosome transport	IMP	25783203
collagen metabolic process	IMP	27435297
protein transport	IMP	15052268
megakaryocyte development	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

collagen metabolic process

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

macromolecule modification [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

cellular process [inference]

vesicle-mediated transport

endosome to lysosome transport

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

megakaryocyte development

cellular localization [inference]

intracellular transport

intracellular protein transport

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

intracellular protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

vesicle fusion [inference]

phagosome-lysosome fusion

endosome organization

secretory granule organization [inference]

platelet alpha granule organization

organelle fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

phagosome-lysosome fusion

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

membrane organization [inference]

membrane fusion

organelle membrane fusion [inference]

vesicle fusion [inference]

phagosome-lysosome fusion

supramolecular fiber organization [inference]

collagen fibril organization

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

skin morphogenesis

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

megakaryocyte development

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

megakaryocyte development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

intracellular protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

endosome to lysosome transport

intracellular transport

intracellular protein transport

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

organic substance transport [inference]

protein transport

intracellular protein transport

nitrogen compound transport [inference]

protein transport

intracellular protein transport

establishment of protein localization [inference]

protein transport

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport

intracellular protein transport

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

organelle localization [inference]

vesicle localization [inference]

pigment granule localization [inference]

melanosome localization

vacuolar localization [inference]

lysosome localization

cellular localization [inference]

intracellular transport

intracellular protein transport

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

regulation of homotypic cell-cell adhesion [inference]

regulation of platelet aggregation

regulation of cell activation [inference]

regulation of platelet activation [inference]

regulation of platelet aggregation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of platelet activation [inference]

regulation of platelet aggregation

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
recycling endosome	IEA
Golgi apparatus	IDA	27435297
platelet alpha granule	IDA	16123220
late endosome	IDA	15052268
HOPS complex	IDA	19109425 25783203

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

HOPS complex

vesicle tethering complex

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

coated vesicle [inference]

clathrin-coated vesicle

secretory vesicle [inference]

secretory granule [inference]

platelet alpha granule

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

coated vesicle [inference]

clathrin-coated vesicle

secretory vesicle [inference]

secretory granule [inference]

platelet alpha granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

coated vesicle [inference]

clathrin-coated vesicle

secretory vesicle [inference]

secretory granule [inference]

platelet alpha granule

perinuclear region of cytoplasm

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16189514 18474358 19109425 20190753 22677173 23901104 23918659 25416956 25783203 26871637 28017832 29778605 32296183
protein-containing complex binding	IPI	21411634

GO Hierarchy

molecular function

binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Vacuolar protein sorting-associated protein

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 6** entries
InterPro
Sec1-like protein
Sec1-like superfamily
Sec1-like, domain 1
Sec1-like, domain 2
Sec1-like, domain 3a
Vacuolar protein sorting-associated protein 33, domain 3b

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0050763	ARC syndrome	Alliance of Genome Resources
DOID:0070221	progressive familial intrahepatic cholestasis	Alliance of Genome Resources
DOID:0080954	arthrogryposis multiplex congenita	Alliance of Genome Resources
DOID:0111353	arthrogryposis, renal dysfunction, and cholestasis 1	Alliance of Genome Resources
DOID:13580	cholestasis	Alliance of Genome Resources
DOID:557	kidney disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	43077		FB:FBgn0039335
Rattus norvegicus	64060		RGD:620644	RATNO15989
Caenorhabditis elegans	174095		WB:WBGene00016960
Mus musculus	233405		MGI:2446237	MOUSE54026
Pan troglodytes	453657	9598_0:003e39		PANTR11185
Canis lupus familiaris	479048			CANLF12071
Bos taurus	526538			BOVIN16417
Danio rerio	541534		ZFIN:ZDB-GENE-050327-73	DANRE40178
Saccharomyces cerevisiae S288C	851112		SGD:S000004388
Monodelphis domestica	100012313			MONDO04931