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phospholipase A2 group IID

Summary

Gene Symbol

PLA2G2D

Aliases

sPLA2S

Organism

Homo sapiens (human)

External Links

NCBI Gene

26279

HGNC

9033

KEGG Gene ID

hsa:26279

PubChem

26279

Alliance of Genome Resources

HGNC:9033

Annotation

Keyword

Alternative splicing
Calcium
Disulfide bond
Glycoprotein
Hydrolase
Lipid degradation
Metal-binding
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UNK4	PLA2IID Phosphatidylcholine 2-acylhydrolase 2D Secretory-type PLA, stroma-associated homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
negative regulation of T cell proliferation	IBA
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IEA
regulation of acute inflammatory response to antigenic stimulus	ISS
phosphatidylethanolamine metabolic process	ISS
inflammatory response		10455175

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

regulatory T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

T cell activation [inference]

T cell differentiation [inference]

regulatory T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process

catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process

organic substance catabolic process [inference]

lipid catabolic process

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

regulatory T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

T cell activation [inference]

T cell differentiation [inference]

regulatory T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

regulatory T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

regulatory T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

T cell activation [inference]

T cell differentiation [inference]

regulatory T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

regulatory T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

icosanoid secretion [inference]

arachidonic acid secretion

organic substance transport [inference]

lipid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

arachidonate transport [inference]

arachidonic acid secretion

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

arachidonate transport [inference]

arachidonic acid secretion

icosanoid transport [inference]

icosanoid secretion [inference]

arachidonic acid secretion

arachidonate transport [inference]

arachidonic acid secretion

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

arachidonate transport [inference]

arachidonic acid secretion

icosanoid transport [inference]

icosanoid secretion [inference]

arachidonic acid secretion

arachidonate transport [inference]

arachidonic acid secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

regulation of immune response [inference]

regulation of inflammatory response to antigenic stimulus [inference]

regulation of acute inflammatory response to antigenic stimulus

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of cell population proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of inflammatory response [inference]

regulation of acute inflammatory response [inference]

regulation of acute inflammatory response to antigenic stimulus

regulation of inflammatory response to antigenic stimulus [inference]

regulation of acute inflammatory response to antigenic stimulus

regulation of immune response [inference]

regulation of inflammatory response to antigenic stimulus [inference]

regulation of acute inflammatory response to antigenic stimulus

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response [inference]

regulation of acute inflammatory response [inference]

regulation of acute inflammatory response to antigenic stimulus

regulation of inflammatory response to antigenic stimulus [inference]

regulation of acute inflammatory response to antigenic stimulus

regulation of cellular process [inference]

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

regulation of leukocyte cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

negative regulation of leukocyte proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of cell population proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

Displaying 1 entry
GO Term	Evidence Code	PMID
extracellular region

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
phospholipase A2 activity		10455175
heparin binding	IEA
calcium-dependent phospholipase A2 activity	IBA IDA	10681567
calcium ion binding	IBA
heparan sulfate proteoglycan binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

phospholipase A2 activity

calcium-dependent phospholipase A2 activity

carboxylic ester hydrolase activity [inference]

phospholipase A2 activity

calcium-dependent phospholipase A2 activity

binding [inference]

protein binding [inference]

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

lipid binding [inference]

phospholipid binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

sulfur compound binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

Rhea

RHEA:15801

H₂O + a 1,2-diacyl-sn-glycero-3-phosphocholine

H⁺ + a fatty acid + a 1-acyl-sn-glycero-3-phosphocholine

Enzyme

3.1.1.4

PMID

RHEA:36231

H₂O + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine

H⁺ + a fatty acid + 1-O-alkyl-sn-glycero-3-phosphocholine

Enzyme

3.1.1.4

PMID

9442064

Disease

Disease Ontology

Displaying entries **1 - 10** of 20 in total

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DO ID	Disease Name	Source
DOID:0060643	primary sclerosing cholangitis	DisGeNET
DOID:14250	Down syndrome	DisGeNET
DOID:14268	sclerosing cholangitis	DisGeNET
DOID:14269	suppurative cholangitis	DisGeNET
DOID:14270	ascending cholangitis	DisGeNET
DOID:1520	colon carcinoma	DisGeNET
DOID:1612	breast cancer	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:1936	atherosclerosis	DisGeNET DisGeNET
DOID:219	colon cancer	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000282
Gene Name: phospholipase A2, group IID

Ortholog

Displaying entries **1 - 10** of 53 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	43461	FB:FBgn0039655
Sarcophilus harrisii	100930695		SARHA11366
Callithrix jacchus	100410833		CALJA39645
Cercocebus atys	105595053		CERAT06485
Macaca mulatta	704735		MACMU21226
Macaca nemestrina	105483097		MACNE33859
Papio anubis	101020610		PAPAN20931
Mandrillus leucophaeus	105532242		MANLE37232
Gorilla gorilla gorilla	101153162		GORGO19169
Pan paniscus	100975186		PANPA00488

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Summary

External Links

Annotation

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements