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glucosaminyl (N-acetyl) transferase 1

Summary

Gene Symbol

GCNT1

Aliases

C2GNT
NAGCT2
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N--acetylglucosaminyltransferase
core 2 beta1,6 N-acetylglucosaminyltransferase-I

Organism

Homo sapiens (human)

External Links

NCBI Gene

2650

GGDB ID

gg109

HGNC

4203

mRNA

NM_001490

map

9q13

Protein

NP_001481

OMIM

600391

KEGG Gene ID

hsa:2650

PubChem

2650

Alliance of Genome Resources

HGNC:4203

Annotation

Keyword

Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q02742	Core 2 beta-1,6-N-acetylglucosaminyltransferase Core 2-branching enzyme Core2-GlcNAc-transferase Leukocyte type core 2 beta-1,6-N-acetylglucosaminyltransferase
Q86T81

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
glycoprotein biosynthetic process	IMP	23027862
O-glycan processing	TAS
O-glycan processing, core 2	IDA	1329093
response to insulin	IEA
tissue morphogenesis	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

O-glycan processing

O-glycan processing, core 2

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

O-glycan processing

O-glycan processing, core 2

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

O-glycan processing

O-glycan processing, core 2

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

O-glycan processing

O-glycan processing, core 2

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

O-glycan processing

O-glycan processing, core 2

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

O-glycan processing

O-glycan processing, core 2

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

O-glycan processing

O-glycan processing, core 2

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

leukocyte cell-cell adhesion [inference]

leukocyte adhesion to vascular endothelial cell [inference]

leukocyte tethering or rolling

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

cell adhesion molecule production

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

kidney morphogenesis

tissue morphogenesis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of leukocyte migration [inference]

regulation of cellular extravasation [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

regulation of cellular extravasation [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

regulation of leukocyte adhesion to vascular endothelial cell [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

regulation of cellular extravasation [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

Displaying **all 5** entries
GO Term	Evidence Code	PMID
Golgi membrane	TAS
extracellular space	IEA
trans-Golgi network	IDA	23027862
membrane	TAS	1329093
Golgi cisterna	IDA	23027862

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity	TAS
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity	IDA	1329093
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity	IBA
protein binding	IPI	23027862

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

beta-1,3-galactosyl-o-glycosyl-glycoprotein beta-1,6-n-acetylglucosaminyltransferase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
transferase activity

Human Protein Atlas

ENSG00000187210

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg109

Gene Symbol

GCNT1

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G00031MO	Ser/Thr (core 2)	G00033MO	Ser/Thr (core 2)	1329093

Displaying **all 5** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G00031MO	[alpha]-pNP	G00033MO	[alpha]-pNP	9915862
UDP-GlcNAc	G00035MO	[alpha]-pNP	G00037MO	[alpha]-pNP	9915862
UDP-GlcNAc	G00031MO	Ser/Thr (core 2)	G00033MO	Ser/Thr (core 2)	1329093
UDP-GlcNAc	G00031MO		G00033MO		9988682
UDP-GlcNAc	G00031MO	[alpha]-1-p-nitrophenyl	G00033MO	[alpha]-1-p-nitrophenyl	9988682

Displaying entries **1 - 5** of 7 in total

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Donor	Acceptor	Reducing terminal(Acceptor)	Reference
UDP-GlcNAc	G00035MO	[alpha]-1-p-nitrophenyl	9988682
UDP-GlcNAc	G00887EN	[beta]1-octyl	9915862
UDP-GlcNAc	G33476GF	methyl	9988682
UDP-GlcNAc	G82440PA	[beta]1-octyl	9915862
UDP-GlcNAc	G57321FI		9988682

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	NP_071612	NM_022276
Mus musculus	NP_034395	NM_010265

KEGG BRITE Database

Orthology

K00727

Name

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase [EC:2.4.1.102]

References

1329093

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05912	2.4.1.102	G00031MO	G00033MO
R05910	2.4.1.102 2.4.1.148	G57321FI	G00041MO

Rhea

RHEA:56212

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.102

PMID

RHEA:56216

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.102

PMID

Ortholog

Displaying entries **1 - 10** of 84 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	2650	Xenbase:XB-GENE-996858
Caenorhabditis elegans	2651	WB:WBGene00001644
Caenorhabditis elegans	9245	WB:WBGene00001644
Mus musculus	14537	Xenbase:XB-GENE-996858	MOUSE26555
Caenorhabditis elegans	14538	WB:WBGene00001644
Caenorhabditis elegans	51301	WB:WBGene00001644
Rattus norvegicus	64043	Xenbase:XB-GENE-996858	RATNO20661
Caenorhabditis elegans	72077	WB:WBGene00001644
Caenorhabditis elegans	140687	WB:WBGene00001644
Xenopus tropicalis	173109	Xenbase:XB-GENE-996858

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements