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glial fibrillary acidic protein

Summary

Gene Symbol

GFAP

Organism

Homo sapiens (human)

External Links

NCBI Gene

2670

PubChem

2670

Alliance of Genome Resources

HGNC:4235

Annotation

Keyword

3D-structure
Alternative splicing
Citrullination
Coiled coil
Cytoplasm
Direct protein sequencing
Disease variant
Intermediate filament
Leukodystrophy
Methylation
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P14136

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
positive regulation of Schwann cell proliferation	IEA
regulation of neurotransmitter uptake	IEA
Bergmann glial cell differentiation	IEA
intracellular protein transport	IEA
intermediate filament organization	IBA IDA	15732097

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

cell population proliferation [inference]

glial cell proliferation [inference]

Schwann cell proliferation

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

intermediate filament-based process [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

astrocyte differentiation [inference]

Bergmann glial cell differentiation

cell development [inference]

glial cell development [inference]

astrocyte development

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection regeneration

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

supramolecular fiber organization [inference]

intermediate filament organization

developmental process [inference]

anatomical structure development [inference]

regeneration [inference]

neuron projection regeneration

cell development [inference]

glial cell development [inference]

astrocyte development

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

astrocyte differentiation [inference]

Bergmann glial cell differentiation

cell development [inference]

glial cell development [inference]

astrocyte development

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

neuron projection regeneration

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

D-aspartate transport [inference]

D-aspartate import across plasma membrane

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transport [inference]

D-aspartate import across plasma membrane

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

D-aspartate transport [inference]

D-aspartate import across plasma membrane

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transport [inference]

D-aspartate import across plasma membrane

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

nitrogen compound transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transport [inference]

D-aspartate import across plasma membrane

protein transport [inference]

intracellular protein transport

import into cell [inference]

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of chaperone-mediated autophagy

regulation of protein catabolic process [inference]

regulation of chaperone-mediated autophagy

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of chaperone-mediated autophagy

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

regulation of chaperone-mediated autophagy

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

regulation of chaperone-mediated autophagy

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

regulation of chaperone-mediated autophagy

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of localization [inference]

regulation of transport [inference]

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter uptake

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

regulation of cellular process [inference]

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of chaperone-mediated autophagy

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

regulation of glial cell proliferation [inference]

regulation of Schwann cell proliferation [inference]

positive regulation of Schwann cell proliferation

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development

regulation of protein-containing complex assembly

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation [inference]

positive regulation of Schwann cell proliferation

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
intermediate filament cytoskeleton	IDA
cell projection	IBA
cell body	IEA
cytoplasmic side of lysosomal membrane	IEA
lysosome	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell projection

plasma membrane bounded cell projection [inference]

glial cell projection [inference]

astrocyte projection [inference]

astrocyte end-foot

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

cell body

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of lysosomal membrane

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

Displaying **all 5** entries
GO Term	Evidence Code	PMID
kinase binding	IEA
protein binding	IPI	16189514 17500595 25416956 25910212 26871637 27229929 29892012 31515488 32296183 32814053 33961781
integrin binding	IEA
identical protein binding	IPI	25416956 25910212 32296183
structural constituent of cytoskeleton	IBA

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of cytoskeleton

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

enzyme binding [inference]

kinase binding

identical protein binding

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Keratin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
intermediate filament organization

Displaying **all 2** entries
InterPro
Intermediate filament protein, conserved site
Intermediate filament, rod domain

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:4252	Alexander disease	Alliance of Genome Resources
DOID:4724	brain edema	Alliance of Genome Resources
DOID:5679	retinal disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	14580		MGI:95697	MOUSE05493
Rattus norvegicus	24387		RGD:2679	RATNO03505
Danio rerio	30646		ZFIN:ZDB-GENE-990914-3	DANRE30526
Caenorhabditis elegans	180430		WB:WBGene00002058
Bos taurus	281189			BOVIN13525
Sus scrofa	396562			PIGXX02132
Ovis aries	443220			SHEEP03171
Ciona intestinalis	445691			CIOIN10748
Pan troglodytes	454741	9598_0:00439a		PANTR13704
Canis lupus familiaris	480495			CANLF18622

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements