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gamma-glutamyl carboxylase

Summary

Gene Symbol

GGCX

Organism

Homo sapiens (human)

External Links

NCBI Gene

2677

PubChem

2677

Alliance of Genome Resources

HGNC:4247

JoGo

GGCX

TogoVar

GGCX

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Disease variant
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Lipid-binding
Lyase
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A8I5QJA4
P38435	Gamma-glutamyl carboxylase Peptidyl-glutamate 4-carboxylase Vitamin K gamma glutamyl carboxylase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

1

2

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Last »
GO Term	Evidence Code	PMID
blood coagulation	TAS	9845520
peptidyl-glutamic acid carboxylation
protein modification process	TAS	1749935
vitamin K metabolic process	IDA	17073445
vitamin K metabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

peptidyl-glutamic acid carboxylation

protein carboxylation [inference]

peptidyl-glutamic acid carboxylation

protein maturation

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

vitamin K metabolic process

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

peptidyl-glutamic acid carboxylation

protein carboxylation [inference]

peptidyl-glutamic acid carboxylation

protein maturation

small molecule metabolic process [inference]

vitamin metabolic process [inference]

fat-soluble vitamin metabolic process [inference]

vitamin K metabolic process

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

vitamin K metabolic process

organic substance metabolic process [inference]

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

vitamin K metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

peptidyl-glutamic acid carboxylation

protein carboxylation [inference]

peptidyl-glutamic acid carboxylation

protein maturation

macromolecule modification [inference]

protein modification process

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

peptidyl-glutamic acid carboxylation

protein carboxylation [inference]

peptidyl-glutamic acid carboxylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

peptidyl-glutamic acid carboxylation

protein carboxylation [inference]

peptidyl-glutamic acid carboxylation

protein maturation

cellular process [inference]

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

vitamin K metabolic process

multicellular organismal process [inference]

coagulation [inference]

blood coagulation

biological regulation [inference]

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum lumen	IEA
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IDA	10910912
membrane	TAS	1749935

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

Displaying **all 4** entries
GO Term	Evidence Code	PMID
gamma-glutamyl carboxylase activity	TAS
gamma-glutamyl carboxylase activity	IDA	17073445
gamma-glutamyl carboxylase activity	IBA
vitamin binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-carbon lyase activity [inference]

carboxy-lyase activity [inference]

gamma-glutamyl carboxylase activity

binding [inference]

small molecule binding [inference]

vitamin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

vitamin k-dependent gamma-carboxylase

Functional Category

G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 2** entries
Gene Ontology
gamma-glutamyl carboxylase activity
vitamin binding

Displaying **all 2** entries
InterPro
HTTM
Vitamin K-dependent gamma-carboxylase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0112173	combined deficiency of vitamin K-dependent clotting factors 1	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements