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gamma-glutamyltransferase 5

Summary

Gene Symbol

GGT5

Aliases

GGT-REL

Organism

Homo sapiens (human)

External Links

NCBI Gene

2687

HGNC

4260

KEGG Gene ID

hsa:2687

PubChem

2687

Alliance of Genome Resources

HGNC:4260

Annotation

Keyword

Acyltransferase
Alternative splicing
Glutathione biosynthesis
Glycoprotein
Leukotriene biosynthesis
Protease
Reference proteome
Signal-anchor
Transferase
Transmembrane helix
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P36269	Gamma-glutamyl transpeptidase-related enzyme Gamma-glutamyltransferase 5 Gamma-glutamyltransferase-like activity 1 Gamma-glutamyltranspeptidase 5 Leukotriene-C4 hydrolase
B4DEL3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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2

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GO Term	Evidence Code	PMID
fatty acid metabolic process	IDA	21447318
leukotriene D4 biosynthetic process	IBA IDA ISS	1676842 21447318
glutathione catabolic process	IBA IDA	1676842 21447318
proteolysis	IDA	1676842
inflammatory response	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

leukotriene D4 biosynthetic process

amide metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

leukotriene D4 biosynthetic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

amino acid metabolic process

protein metabolic process [inference]

proteolysis

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

leukotriene D4 biosynthetic process

catabolic process [inference]

organic substance catabolic process [inference]

glutathione catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

leukotriene D4 biosynthetic process

sulfur compound biosynthetic process [inference]

leukotriene D4 biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

leukotriene D4 biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

leukotriene D4 biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process

icosanoid metabolic process [inference]

leukotriene metabolic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

sulfur compound metabolic process [inference]

sulfur compound biosynthetic process [inference]

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

leukotriene D4 biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

leukotriene D4 biosynthetic process

sulfur compound biosynthetic process [inference]

leukotriene D4 biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

primary metabolic process [inference]

amino acid metabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

leukotriene D4 biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

protein metabolic process [inference]

proteolysis

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process

icosanoid metabolic process [inference]

leukotriene metabolic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process

icosanoid metabolic process [inference]

leukotriene metabolic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

leukotriene D4 biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

glutathione metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

amino acid metabolic process

protein metabolic process [inference]

proteolysis

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

leukotriene D4 biosynthetic process

organic substance catabolic process [inference]

glutathione catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

leukotriene D4 biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

leukotriene D4 biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process

icosanoid metabolic process [inference]

leukotriene metabolic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

sulfur compound metabolic process [inference]

sulfur compound biosynthetic process [inference]

leukotriene D4 biosynthetic process

leukotriene D4 metabolic process [inference]

leukotriene D4 biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

leukotriene D4 biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process [inference]

leukotriene D4 biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

leukotriene D4 biosynthetic process

sulfur compound biosynthetic process [inference]

leukotriene D4 biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

Displaying 1 entry
GO Term	Evidence Code	PMID
plasma membrane	IBA IDA TAS	1676842

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
glutathione hydrolase activity	IBA IDA	1676842
leukotriene C4 gamma-glutamyl transferase activity	IEA
peptidyltransferase activity	IDA	21447318
leukotriene-C(4) hydrolase	IBA IDA	1676842 21447318

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

omega peptidase activity [inference]

threonine-type peptidase activity [inference]

glutathione hydrolase activity

catalytic activity, acting on a protein [inference]

peptidyltransferase activity

peptidase activity [inference]

omega peptidase activity [inference]

threonine-type peptidase activity [inference]

glutathione hydrolase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

peptidyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000099998

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K18592

Name

gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase [EC:2.3.2.2 3.4.19.13 3.4.19.14]

References

Rhea

RHEA:28807

H₂O + glutathione

L-glutamate + L-cysteinylglycine

Enzyme

3.4.19.13

PMID

RHEA:59468

H₂O + an S-substituted glutathione

an S-substituted L-cysteinylglycine + L-glutamate

Enzyme

3.4.19.13

PMID

RHEA:31563

H₂O + leukotriene C₄

L-glutamate + leukotriene D₄

Enzyme

3.4.19.14

PMID

RHEA:23904

an α-amino acid

5-L-glutamyl amino acid

Enzyme

2.3.2.2

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:3571	liver cancer	DisGeNET DisGeNET
DOID:3683	lung benign neoplasm	DisGeNET
DOID:684	hepatocellular carcinoma	DisGeNET DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002268
Gene Name: gamma-glutamyltransferase 5

Ortholog

Displaying entries **1 - 10** of 92 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	178453	WB:WBGene00012416
Drosophila melanogaster	32164	FB:FBgn0030361
Drosophila melanogaster	32672	FB:FBgn0030796
Drosophila melanogaster	32839	FB:FBgn0030932
Drosophila melanogaster	5740847	FB:FBgn0025837
Callorhinchus milii	103179940		CALMI19154
Danio rerio	569734	ZFIN:ZDB-GENE-080226-1	DANRE43019
Danio rerio	100333757	ZFIN:ZDB-GENE-110721-2	DANRE01611
Astyanax mexicanus	103031291		ASTMX05059
Astyanax mexicanus	103046599		ASTMX09985

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements