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mannoside acetylglucosaminyltransferase 4, isoenzyme A

Summary

Gene Symbol

Mgat4a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

269181

KEGG Gene ID

mmu:269181

PubChem

269181

Alliance of Genome Resources

MGI:2662992

Annotation

Keyword

3D-structure
Alternative splicing
Coiled coil
Glycoprotein
Glycosyltransferase
Golgi apparatus
Metal-binding
Phosphoprotein
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q812G0	N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein glycosylation	ISO
protein N-linked glycosylation	IBA IGI	20015870
glyoxylate metabolic process	ISS
N-glycan processing	IDA	16377570

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyoxylate metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

glyoxylate metabolic process

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

glyoxylate metabolic process

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

organic substance metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyoxylate metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

glyoxylate metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyoxylate metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

glyoxylate metabolic process

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
peroxisome	ISS
extracellular region	IEA
Golgi stack	IBA
Golgi membrane	IEA
endoplasmic reticulum	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi stack

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
alanine-glyoxylate transaminase activity	ISS
metal ion binding	IEA
alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	IDA ISO	16377570
acetylglucosaminyltransferase activity	IBA IDA	20015870
glycosyltransferase activity	IDA	24619415

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

transferase activity, transferring nitrogenous groups [inference]

transaminase activity [inference]

alanine-glyoxylate transaminase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

Functional Category

O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 3** entries
Gene Ontology
acetylglucosaminyltransferase activity
metal ion binding
protein N-linked glycosylation

Displaying 1 entry
InterPro
Glycosyl transferase family 54

KEGG BRITE Database

Orthology

K00738

Name

alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A/B [EC:2.4.1.145]

References

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05987	2.4.1.145	G39213VZ	G29011JC

Rhea

RHEA:16057

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.145

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1793	pancreatic cancer	Alliance of Genome Resources

Ortholog

Displaying entries **81 - 90** of **126** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Mus caroli	110291666	10089_0:0002df
Mus pahari	110321430	10093_0:001a39
Meriones unguiculatus	110545443	10047_0:000998
Seriola dumerili	111218149		SERDU03062
Vulpes vulpes	112915172		VULVU06677
Astatotilapia calliptera	113007477		ASTCA12478
Anabas testudineus	113173052		ANATE23858
Pseudonaja textilis	113440876		PSETE12709
Athene cunicularia	113479732		ATHCN02497
Electrophorus electricus	113591090		ELEEL46284

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements