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multiple EGF-like-domains 8

Summary

Gene Symbol

Megf8

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

269878

PubChem

269878

Alliance of Genome Resources

MGI:2446294

Annotation

Keyword

Calcium
Disulfide bond
EGF-like domain
Glycoprotein
Kelch repeat
Laminin EGF-like domain
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P60882	Epidermal growth factor-like protein 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 37 in total

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GO Term	Evidence Code	PMID
embryonic heart tube morphogenesis	IMP	24052814
smoothened signaling pathway	IMP	32966817
determination of left/right symmetry	IMP	25807483
heart development	IMP	32203821 32966817
heart development	IGI	32966817

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

epithelial cilium movement involved in determination of left/right asymmetry

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

smoothened signaling pathway

cell recognition [inference]

neuron recognition [inference]

axonal fasciculation [inference]

fasciculation of sensory neuron axon

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

cell migration involved in gastrulation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection fasciculation [inference]

axonal fasciculation [inference]

fasciculation of sensory neuron axon

protein-containing complex organization [inference]

protein-containing complex assembly

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

left/right pattern formation

embryonic heart tube left/right pattern formation

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

embryonic organ morphogenesis [inference]

embryonic skeletal system morphogenesis

skeletal system morphogenesis [inference]

embryonic skeletal system morphogenesis

appendage morphogenesis [inference]

limb morphogenesis

embryonic limb morphogenesis

embryonic appendage morphogenesis [inference]

embryonic limb morphogenesis

tube morphogenesis [inference]

blood vessel morphogenesis [inference]

artery morphogenesis [inference]

pharyngeal arch artery morphogenesis

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis

embryonic morphogenesis [inference]

embryonic heart tube morphogenesis

embryonic appendage morphogenesis [inference]

embryonic limb morphogenesis

embryonic digit morphogenesis

embryonic organ morphogenesis [inference]

embryonic skeletal system morphogenesis

epiboly involved in gastrulation with mouth forming second

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of an epithelial sheet [inference]

epiboly [inference]

epiboly involved in gastrulation with mouth forming second

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis

craniofacial suture morphogenesis

anatomical structure development [inference]

blood vessel development [inference]

artery development [inference]

aorta development

coronary vasculature development

animal organ development [inference]

heart development

embryonic organ development [inference]

embryonic brain development

appendage development [inference]

limb development

localization [inference]

establishment of localization [inference]

transport [inference]

extracellular transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

epithelial cilium movement involved in determination of left/right asymmetry

microtubule-based transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

epithelial cilium movement involved in determination of left/right asymmetry

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of developmental growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

regulation of chemotaxis [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

regulation of chemotaxis [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of developmental growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

smoothened signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

positive regulation of axon extension involved in axon guidance

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of axonogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

Displaying **all 5** entries
GO Term	Evidence Code	PMID
ubiquitin ligase complex	IDA	32966817
ubiquitin ligase complex	IPI	32966817
nucleus	IDA	19218456
membrane	IDA	19218456
membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

ubiquitin ligase complex

catalytic complex [inference]

transferase complex [inference]

ubiquitin ligase complex

cellular anatomical entity [inference]

membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
molecular_function	ND
calcium ion binding	IEA
protein binding	IPI	32966817 34486668

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

multiple epidermal growth factor-like domains protein 8-like

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 9** entries
InterPro
CUB domain
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site
Kelch-type beta propeller
Laminin-type EGF domain
PSI domain
Spermadhesin, CUB domain superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050545	visceral heterotaxy	Alliance of Genome Resources
DOID:0060234	Carpenter syndrome	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements