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6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

Summary

Gene Symbol

Pfkfb4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

270198

PubChem

270198

Alliance of Genome Resources

MGI:2687284

Annotation

Keyword

ATP-binding
Alternative splicing
Hydrolase
Kinase
Multifunctional enzyme
Nucleotide-binding
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6DTY7	6PF-2-K/Fru-2,6-P2ase testis-type isozyme
C9VZF2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
carbohydrate phosphorylation	IEA
fructose metabolic process	IEA
fructose 2,6-bisphosphate metabolic process	IBA IEA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

phosphorylation [inference]

carbohydrate phosphorylation

organophosphate metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

carbohydrate phosphorylation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

carbohydrate phosphorylation

organophosphate metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

carbohydrate derivative metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

phosphorylation [inference]

carbohydrate phosphorylation

organophosphate metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
cytosol	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

Displaying **all 3** entries
GO Term	Evidence Code	PMID
6-phosphofructo-2-kinase activity	IBA ISO
fructose-2,6-bisphosphate 2-phosphatase activity	IBA IEA ISO
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

carbohydrate kinase activity [inference]

phosphofructokinase activity [inference]

6-phosphofructo-2-kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

phosphofructokinase activity [inference]

6-phosphofructo-2-kinase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

carbohydrate phosphatase activity [inference]

sugar-phosphatase activity [inference]

fructose-2,6-bisphosphate 2-phosphatase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4

Functional Category

C: Energy production and conversion
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 10** entries
Gene Ontology
6-phosphofructo-2-kinase activity
ATP binding
carbohydrate phosphorylation
catalytic activity
fructose 2,6-bisphosphate metabolic process
fructose metabolic process
hydrolase activity
kinase activity
nucleotide binding
phosphorylation

Displaying **all 6** entries
InterPro
6-phosphofructo-2-kinase
Fructose-2,6-bisphosphatase
Histidine phosphatase superfamily, clade-1
Histidine phosphatase superfamily
P-loop containing nucleoside triphosphate hydrolase
Phosphoglycerate/bisphosphoglycerate mutase, active site

Rhea

ATP + β-D-fructose 6-phosphate

H⁺ + ADP + β-D-fructose 2,6-bisphosphate

Enzyme

2.7.1.105

PMID

H₂O + β-D-fructose 2,6-bisphosphate

phosphate + β-D-fructose 6-phosphate

Enzyme

3.1.3.46

PMID

Ortholog

Displaying entries **1 - 10** of **123** in total

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Next ›

Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	5210		HGNC:8875	HUMAN69843
Drosophila melanogaster	32938		FB:FBgn0027621
Rattus norvegicus	54283	10116_1:002deb	RGD:3310	RATNO41951
Caenorhabditis elegans	172147		WB:WBGene00022456
Caenorhabditis elegans	177363		WB:WBGene00019295
Danio rerio	386663		ZFIN:ZDB-GENE-031031-4	DANRE38506
Xenopus tropicalis	407880		Xenbase:XB-GENE-1001570
Pan troglodytes	460346			PANTR31062
Danio rerio	556190		ZFIN:ZDB-GENE-051120-51	DANRE01805
Macaca mulatta	709854			MACMU29263

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Last updated: December 9, 2024