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growth hormone inducible transmembrane protein

Summary

Gene Symbol

GHITM

Organism

Homo sapiens (human)

External Links

NCBI Gene

27069

PubChem

27069

Alliance of Genome Resources

HGNC:17281

Annotation

Keyword

Apoptosis
Mitochondrion inner membrane
Proteomics identification
Reference proteome
Transit peptide
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9H3K2	Dermal papilla-derived protein 2 Mitochondrial morphology and cristae structure 1 Transmembrane BAX inhibitor motif-containing protein 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
calcium ion transport	IMP	36321428
mitochondrial calcium ion transmembrane transport	IMP	35912435
apoptotic process	IEA
inner mitochondrial membrane organization	IMP	18417609 32977469 36321428
inner mitochondrial membrane organization	IBA

GO Hierarchy

biological process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

calcium export from the mitochondrion

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol [inference]

calcium export from the mitochondrion

potassium ion transmembrane transport [inference]

mitochondrial potassium ion transmembrane transport

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

calcium export from the mitochondrion

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol [inference]

calcium export from the mitochondrion

potassium ion transmembrane transport [inference]

mitochondrial potassium ion transmembrane transport

proton transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

mitochondrial membrane organization [inference]

inner mitochondrial membrane organization

membrane organization [inference]

mitochondrial membrane organization [inference]

inner mitochondrial membrane organization

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport [inference]

mitochondrial potassium ion transmembrane transport

calcium ion transport

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

calcium export from the mitochondrion

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol [inference]

calcium export from the mitochondrion

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

calcium export from the mitochondrion

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol [inference]

calcium export from the mitochondrion

potassium ion transmembrane transport [inference]

mitochondrial potassium ion transmembrane transport

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

calcium export from the mitochondrion

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol [inference]

calcium export from the mitochondrion

potassium ion transmembrane transport [inference]

mitochondrial potassium ion transmembrane transport

proton transmembrane transport

mitochondrial transport [inference]

mitochondrial calcium ion transmembrane transport

calcium export from the mitochondrion

mitochondrial potassium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

calcium export from the mitochondrion

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol [inference]

calcium export from the mitochondrion

potassium ion transmembrane transport [inference]

mitochondrial potassium ion transmembrane transport

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

calcium export from the mitochondrion

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol [inference]

calcium export from the mitochondrion

potassium ion transmembrane transport [inference]

mitochondrial potassium ion transmembrane transport

proton transmembrane transport

organic substance transport [inference]

calcium ion transport

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

calcium export from the mitochondrion

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol [inference]

calcium export from the mitochondrion

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of mitochondrial ATP synthesis coupled electron transport

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of mitochondrial ATP synthesis coupled electron transport

regulation of generation of precursor metabolites and energy [inference]

regulation of mitochondrial ATP synthesis coupled electron transport [inference]

positive regulation of mitochondrial ATP synthesis coupled electron transport

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of release of cytochrome c from mitochondria

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of release of cytochrome c from mitochondria

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of release of cytochrome c from mitochondria

regulation of localization [inference]

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol [inference]

calcium export from the mitochondrion

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of mitochondrial ATP synthesis coupled electron transport

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of mitochondrial ATP synthesis coupled electron transport

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of release of cytochrome c from mitochondria

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of release of cytochrome c from mitochondria

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of release of cytochrome c from mitochondria

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of release of cytochrome c from mitochondria

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol [inference]

calcium export from the mitochondrion

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of release of cytochrome c from mitochondria

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of release of cytochrome c from mitochondria

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of release of cytochrome c from mitochondria

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of release of cytochrome c from mitochondria

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of release of cytochrome c from mitochondria

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of release of cytochrome c from mitochondria

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of release of cytochrome c from mitochondria

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of mitochondrial ATP synthesis coupled electron transport

regulation of generation of precursor metabolites and energy [inference]

regulation of mitochondrial ATP synthesis coupled electron transport [inference]

positive regulation of mitochondrial ATP synthesis coupled electron transport

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of release of cytochrome c from mitochondria

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of release of cytochrome c from mitochondria

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of release of cytochrome c from mitochondria

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of mitochondrial ATP synthesis coupled electron transport

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of release of cytochrome c from mitochondria

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of release of cytochrome c from mitochondria

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of release of cytochrome c from mitochondria

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol [inference]

calcium export from the mitochondrion

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of release of cytochrome c from mitochondria

regulation of mitochondrion organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of release of cytochrome c from mitochondria

regulation of release of cytochrome c from mitochondria [inference]

negative regulation of release of cytochrome c from mitochondria

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of release of cytochrome c from mitochondria

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol [inference]

calcium export from the mitochondrion

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
mitochondrion	IDA
mitochondrion	HTP	34800366
mitochondrial inner membrane	IDA	18417609
mitochondrial inner membrane	IBA
endoplasmic reticulum membrane	IDA	25764978

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
calcium channel activity	IBA
protein binding	IPI	21903422 32296183 32353859 32814053 33060197 35912435 36217030 36321428
calcium:proton antiporter activity	IMP	36321428