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lysosomal associated membrane protein 3

Summary

Gene Symbol

LAMP3

Organism

Homo sapiens (human)

External Links

NCBI Gene

27074

PubChem

27074

Alliance of Genome Resources

HGNC:14582

Annotation

Keyword

3D-structure
Adaptive immunity
Cytoplasmic vesicle
Disulfide bond
Endosome
Glycoprotein
Host-virus interaction
Lysosome
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UQV4	DC-lysosome-associated membrane glycoprotein Protein TSC403

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
adaptive immune response	IEA
regulation of autophagy	IMP	25681212
positive regulation of gene expression	IMP	23651994
response to interferon-alpha	IMP	23651994
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response

cellular process [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle

establishment of protein localization [inference]

establishment of protein localization to organelle

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

response to stimulus [inference]

immune response [inference]

adaptive immune response

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to interferon-alpha

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle

establishment of protein localization [inference]

establishment of protein localization to organelle

establishment of localization [inference]

establishment of protein localization [inference]

establishment of protein localization to organelle

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle

establishment of protein localization [inference]

establishment of protein localization to organelle

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

regulation of cellular catabolic process [inference]

regulation of autophagy

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular catabolic process [inference]

regulation of autophagy

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of viral process [inference]

regulation of viral life cycle

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular catabolic process [inference]

regulation of autophagy

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
lysosomal membrane	IBA
early endosome	IDA	21810281
plasma membrane	IDA	21810281
plasma membrane	IBA
cell surface	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

secretory granule membrane [inference]

lamellar body membrane [inference]

alveolar lamellar body membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

secretory granule membrane [inference]

lamellar body membrane [inference]

alveolar lamellar body membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

perinuclear region of cytoplasm

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

lysosome-associated membrane

Functional Category

I: Lipid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
establishment of protein localization to organelle

Displaying **all 2** entries
InterPro
Lysosome-associated membrane glycoprotein 2-like, luminal domains
Lysosome-associated membrane glycoprotein

Ortholog

Displaying entries **1 - 10** of 42 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	27074	Xenbase:XB-GENE-954502
Mus musculus	239739	Xenbase:XB-GENE-954502	MOUSE18470
Rattus norvegicus	303801	Xenbase:XB-GENE-954502	RATNO03988
Bos taurus	531327		BOVIN14914
Macaca mulatta	574213		MACMU28276
Pan troglodytes	746899		PANTR32754
Equus caballus	100058615		HORSE14927
Ornithorhynchus anatinus	100073462		ORNAN11632
Pongo abelii	100437850		PONAB26240
Ailuropoda melanoleuca	100464860		AILME03717

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements