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glycerol kinase

Summary

Gene Symbol

Aliases

Organism

Homo sapiens (human)

External Links

NCBI Gene

2710

HGNC

4289

KEGG Gene ID

hsa:2710

PubChem

2710

Alliance of Genome Resources

HGNC:4289

Annotation

Keyword

ATP-binding
Alternative splicing
Cytoplasm
Disease variant
Glycerol metabolism
Kinase
Metal-binding
Mitochondrion outer membrane
Nucleus
Proteomics identification
Reference proteome
Transmembrane helix
Zinc

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B4DH54
P32189	ATP:glycerol 3-phosphotransferase
A0A8I5KXY7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
triglyceride metabolic process	IBA IMP	8651297
triglyceride biosynthetic process	TAS
phosphorylation	IBA
glycerol catabolic process	IEA
glycerol-3-phosphate biosynthetic process	IBA IDA IMP	37021775 8651297

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

organophosphate biosynthetic process [inference]

glycerol-3-phosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycerol-3-phosphate biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process [inference]

glycerol-3-phosphate biosynthetic process

organophosphate metabolic process [inference]

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process [inference]

glycerol-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

glycerol-3-phosphate biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

alditol metabolic process [inference]

glycerol metabolic process

glycerol catabolic process

alditol catabolic process [inference]

glycerol catabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

glycerol catabolic process

alditol catabolic process [inference]

glycerol catabolic process

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

alditol metabolic process [inference]

glycerol metabolic process

glycerol catabolic process

alditol catabolic process [inference]

glycerol catabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

organophosphate metabolic process [inference]

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process [inference]

glycerol-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

glycerol-3-phosphate biosynthetic process

carbohydrate derivative metabolic process [inference]

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process [inference]

glycerol-3-phosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycerol-3-phosphate biosynthetic process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

organophosphate biosynthetic process [inference]

glycerol-3-phosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycerol-3-phosphate biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

glycerol catabolic process

alditol catabolic process [inference]

glycerol catabolic process

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process [inference]

glycerol-3-phosphate biosynthetic process

organophosphate metabolic process [inference]

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process [inference]

glycerol-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

glycerol-3-phosphate biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleus	IEA
cytosol	TAS
mitochondrial outer membrane	IEA
mitochondrion	IBA
extracellular exosome	HDA	19056867

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
glycerol kinase activity	IBA IDA IMP NAS TAS	37021775 8401584 8651297
metal ion binding	IEA
ATP binding	IEA
protein binding	IPI	21988832

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

glycerol kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

glycerol kinase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000198814

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00864

Name

glycerol kinase [EC:2.7.1.30]

References

14756771

Rhea

RHEA:21644

glycerol + ATP

H⁺ + ADP + sn-glycerol 3-phosphate

Enzyme

2.7.1.30

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of **104** in total

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DO ID	Disease Name	Source
DOID:0060874	isolated growth hormone deficiency type IB	DisGeNET
DOID:0050557	congenital muscular dystrophy	DisGeNET
DOID:0050572	cone-rod dystrophy	DisGeNET
DOID:0050630	Aland Island eye disease	DisGeNET
DOID:0060255	rippling muscle disease 2	DisGeNET
DOID:0060363	glycerol kinase deficiency	DisGeNET Alliance of Genome Resources
DOID:0060427	chromosome Xp21 deletion syndrome	DisGeNET
DOID:0060870	isolated growth hormone deficiency	DisGeNET
DOID:0060872	isolated growth hormone deficiency type II	DisGeNET
DOID:0060873	isolated growth hormone deficiency type IA	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 35 in total

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HPO ID	HPO Term
HP:0000028	Cryptorchidism
HP:0000316	Hypertelorism
HP:0000369	Low-set ears
HP:0000486	Strabismus
HP:0000846	Adrenal insufficiency
HP:0000939	Osteoporosis
HP:0001249	Intellectual disability
HP:0001250	Seizure
HP:0001254	Lethargy
HP:0001259	Coma

Displaying 1 entry
Disease ID	Disease Name
OMIM:307030	inborn glycerol kinase deficiency

PubChem Disease

MedGen Diseases

Inborn glycerol kinase deficiency

OMIM Phenotypes

GLYCEROL KINASE DEFICIENCY; GKD

KEGG Diseases

Glycerol kinase deficiency

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001251
Gene Name: glycerol kinase

Ortholog

Displaying entries **21 - 30** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Oreochromis niloticus	100693874		ORENI43197
Oreochromis niloticus	100710600		ORENI21886
Sparus aurata	115577235		SPAAU65695
Sparus aurata	115588215		SPAAU28515
Xenopus laevis	380332	Xenbase:XB-GENE-961547
Xenopus laevis	108708388	Xenbase:XB-GENE-17346316
Xenopus tropicalis	100038285	Xenbase:XB-GENE-961541
Crocodylus porosus	109305948		CROPO02612
Pseudonaja textilis	113446424		PSETE19581
Meleagris gallopavo	100546541		MELGA01374

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements