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glycerol kinase 2

Summary

Gene Symbol

GK2

Aliases

GKTA

Organism

Homo sapiens (human)

External Links

NCBI Gene

2712

HGNC

4291

KEGG Gene ID

hsa:2712

PubChem

2712

Alliance of Genome Resources

HGNC:4291

Annotation

Keyword

ATP-binding
Cytoplasm
Glycerol metabolism
Kinase
Mitochondrion outer membrane
Reference proteome
Spermatogenesis
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A140VKG0
Q14410	ATP:glycerol 3-phosphotransferase 2 Glycerol kinase, testis specific 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
triglyceride metabolic process	IBA
sperm mitochondrial sheath assembly	ISS
glycerol metabolic process	IBA
spermatogenesis	ISS
phosphorylation	IEA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

biosynthetic process [inference]

organic substance biosynthetic process [inference]

organophosphate biosynthetic process [inference]

glycerol-3-phosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycerol-3-phosphate biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process [inference]

glycerol-3-phosphate biosynthetic process

organophosphate metabolic process [inference]

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process [inference]

glycerol-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

glycerol-3-phosphate biosynthetic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

alditol metabolic process [inference]

glycerol metabolic process

glycerol catabolic process

alditol catabolic process [inference]

glycerol catabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

glycerol catabolic process

alditol catabolic process [inference]

glycerol catabolic process

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

alditol metabolic process [inference]

glycerol metabolic process

glycerol catabolic process

alditol catabolic process [inference]

glycerol catabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

organophosphate metabolic process [inference]

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process [inference]

glycerol-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

glycerol-3-phosphate biosynthetic process

carbohydrate derivative metabolic process [inference]

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process [inference]

glycerol-3-phosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycerol-3-phosphate biosynthetic process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

organic substance biosynthetic process [inference]

organophosphate biosynthetic process [inference]

glycerol-3-phosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycerol-3-phosphate biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

glycerol catabolic process

alditol catabolic process [inference]

glycerol catabolic process

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement [inference]

cilium movement involved in cell motility [inference]

flagellated sperm motility

cellular process involved in reproduction in multicellular organism [inference]

sperm mitochondrial sheath assembly

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process [inference]

glycerol-3-phosphate biosynthetic process

organophosphate metabolic process [inference]

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process [inference]

glycerol-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

glycerol-3-phosphate biosynthetic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

cell motility [inference]

cilium or flagellum-dependent cell motility [inference]

cilium-dependent cell motility [inference]

flagellated sperm motility

sperm motility [inference]

flagellated sperm motility

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

sperm mitochondrial sheath assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

cellular process involved in reproduction in multicellular organism [inference]

sperm mitochondrial sheath assembly

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

sperm motility [inference]

flagellated sperm motility

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

Displaying **all 5** entries
GO Term	Evidence Code	PMID
sperm midpiece	IDA	28852571
sperm mitochondrial sheath	ISS
mitochondrial outer membrane	ISS
mitochondrion	HTP IBA	34800366
extracellular exosome	HDA	19056867

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	28852571
glycerol kinase activity	IBA NAS	7987308
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

glycerol kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

glycerol kinase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Glycerol kinase

Functional Category

C: Energy production and conversion
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 12 in total

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Gene Ontology
ATP binding
glycerol catabolic process
glycerol kinase activity
glycerol metabolic process
glycerol-3-phosphate biosynthetic process
glycerol-3-phosphate metabolic process
kinase activity
nucleotide binding
phosphorylation
phosphotransferase activity, alcohol group as acceptor

Displaying **all 6** entries
InterPro
ATPase, nucleotide binding domain
Carbohydrate kinase FGGY, C-terminal
Carbohydrate kinase FGGY, N-terminal
Carbohydrate kinase, FGGY, conserved site
Carbohydrate kinase, FGGY
Glycerol kinase

KEGG BRITE Database

Orthology

K00864

Name

glycerol kinase [EC:2.7.1.30]

References

14756771

Rhea

glycerol + ATP

H⁺ + ADP + sn-glycerol 3-phosphate

Enzyme

2.7.1.30

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060363	glycerol kinase deficiency	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006643
Gene Name: glycerol kinase 2

Ortholog

Displaying entries **1 - 10** of 70 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	14626		MGI:1329027	MOUSE46069
Drosophila melanogaster	36282		FB:FBgn0033673
Drosophila melanogaster	38221		FB:FBgn0035266
Drosophila melanogaster	43913		FB:FBgn0025592
Caenorhabditis elegans	173747		WB:WBGene00020007
Rattus norvegicus	289481		RGD:1303263	RATNO08298
Canis lupus familiaris	478448			CANLF13009
Bos taurus	540143			BOVIN31737
Macaca mulatta	696635			MACMU36484
Saccharomyces cerevisiae S288C	856353		SGD:S000001024

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Last updated: December 9, 2024