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inturned planar cell polarity protein

Summary

Gene Symbol

INTU

Organism

Homo sapiens (human)

External Links

NCBI Gene

27152

PubChem

27152

Alliance of Genome Resources

HGNC:29239

Annotation

Keyword

3D-structure
Alternative splicing
Cell projection
Ciliopathy
Cilium biogenesis/degradation
Cytoskeleton
Developmental protein
Disease variant
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9ULD6	Inturned planar cell polarity effector homolog PDZ domain-containing protein 6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **16 - 20** of 24 in total

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GO Term	Evidence Code	PMID
regulation of smoothened signaling pathway	ISS
motile cilium assembly	IEA
protein localization to organelle	IEA
cell division	IEA
regulation of cilium assembly	NAS	27158779

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

transport along microtubule [inference]

intraciliary transport

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

vesicle-mediated transport

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

cell division

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

intraciliary transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

dorsal/ventral pattern formation [inference]

spinal cord dorsal/ventral patterning

molting cycle process [inference]

hair cycle process [inference]

hair follicle morphogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

establishment of tissue polarity [inference]

establishment of planar polarity

animal organ morphogenesis [inference]

sensory organ morphogenesis [inference]

tongue morphogenesis

hair follicle morphogenesis

embryonic morphogenesis [inference]

embryonic digit morphogenesis

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

neural tube development

tube development [inference]

neural tube development

system development [inference]

nervous system development

appendage development [inference]

limb development

roof of mouth development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

localization [inference]

protein-containing complex localization [inference]

intraciliary transport

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

intraciliary transport

microtubule-based transport [inference]

transport along microtubule [inference]

intraciliary transport

establishment of localization in cell [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

intraciliary transport

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

intraciliary transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway

positive regulation of smoothened signaling pathway

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of keratinocyte proliferation

negative regulation of cell division

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway

positive regulation of smoothened signaling pathway

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway

positive regulation of smoothened signaling pathway

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of keratinocyte proliferation

regulation of epithelial cell proliferation [inference]

regulation of keratinocyte proliferation [inference]

negative regulation of keratinocyte proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of keratinocyte proliferation

regulation of cellular component biogenesis [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of cilium assembly

regulation of organelle assembly [inference]

regulation of cilium assembly

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of keratinocyte proliferation

negative regulation of cell division

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of cilium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of cilium assembly

regulation of organelle organization [inference]

regulation of organelle assembly [inference]

regulation of cilium assembly

regulation of cell division [inference]

negative regulation of cell division

regulation of multicellular organismal process [inference]

regulation of ossification

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
motile cilium	IDA	26644512
cell surface	IEA
centriole	IEA
ciliary transition zone	IEA
ciliary basal body	IDA	26644512

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

microtubule organizing center [inference]

ciliary basal body

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

motile cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

motile cilium

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

centriole

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

centriole

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	26644512 27173435 33961781
phosphatidylinositol binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

inturned

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
cell projection organization
establishment of planar polarity
nervous system development

Displaying **all 6** entries
InterPro
CCZ1/INTU, second Longin domain
CCZ1/INTU/HPS4, third Longin domain
CCZ1/INTU/HSP4, first Longin domain
PDZ domain
PDZ superfamily
Protein inturned

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050592	asphyxiating thoracic dystrophy	Alliance of Genome Resources
DOID:0080289	orofaciodigital syndrome XVII	Alliance of Genome Resources

Ortholog

Displaying entries **71 - 76** of 76 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Chelonoidis abingdonii	116839817		CHEAB20478
Rhinolophus ferrumequinum	117037409		RHIFE14947
Balaenoptera musculus	118896116		BALMU28539
Panthera leo	122217876		PANLE27560
Ursus americanus	123793295		URSAM14024
Pongo pygmaeus	129035040	9600_0:00155b