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inturned planar cell polarity protein

Summary

Gene Symbol

INTU

Organism

Homo sapiens (human)

External Links

NCBI Gene

27152

PubChem

27152

Alliance of Genome Resources

HGNC:29239

Annotation

Keyword

3D-structure
Alternative splicing
Cell projection
Ciliopathy
Cilium biogenesis/degradation
Cytoskeleton
Developmental protein
Disease variant
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9ULD6	Inturned planar cell polarity effector homolog PDZ domain-containing protein 6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 24** of 24 in total

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GO Term	Evidence Code	PMID
spinal cord dorsal/ventral patterning	IEA
negative regulation of keratinocyte proliferation	IEA
keratinocyte differentiation	IEA
embryonic digit morphogenesis	IMP	27158779

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

transport along microtubule [inference]

intraciliary transport

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

vesicle-mediated transport

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

cell division

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

intraciliary transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

dorsal/ventral pattern formation [inference]

spinal cord dorsal/ventral patterning

molting cycle process [inference]

hair cycle process [inference]

hair follicle morphogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

establishment of tissue polarity [inference]

establishment of planar polarity

animal organ morphogenesis [inference]

sensory organ morphogenesis [inference]

tongue morphogenesis

hair follicle morphogenesis

embryonic morphogenesis [inference]

embryonic digit morphogenesis

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

neural tube development

tube development [inference]

neural tube development

system development [inference]

nervous system development

appendage development [inference]

limb development

roof of mouth development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

localization [inference]

protein-containing complex localization [inference]

intraciliary transport

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

intraciliary transport

microtubule-based transport [inference]

transport along microtubule [inference]

intraciliary transport

establishment of localization in cell [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

intraciliary transport

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

intraciliary transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway

positive regulation of smoothened signaling pathway

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of keratinocyte proliferation

negative regulation of cell division

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway

positive regulation of smoothened signaling pathway

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway

positive regulation of smoothened signaling pathway

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of keratinocyte proliferation

regulation of epithelial cell proliferation [inference]

regulation of keratinocyte proliferation [inference]

negative regulation of keratinocyte proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of keratinocyte proliferation

regulation of cellular component biogenesis [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of cilium assembly

regulation of organelle assembly [inference]

regulation of cilium assembly

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of keratinocyte proliferation

negative regulation of cell division

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of cilium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of cilium assembly

regulation of organelle organization [inference]

regulation of organelle assembly [inference]

regulation of cilium assembly

regulation of cell division [inference]

negative regulation of cell division

regulation of multicellular organismal process [inference]

regulation of ossification

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
motile cilium	IDA	26644512
cell surface	IEA
centriole	IEA
ciliary transition zone	IEA
ciliary basal body	IDA	26644512

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

microtubule organizing center [inference]

ciliary basal body

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

motile cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

motile cilium

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

centriole

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

centriole

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	26644512 27173435 33961781
phosphatidylinositol binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

inturned

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
cell projection organization
establishment of planar polarity
nervous system development

Displaying **all 6** entries
InterPro
CCZ1/INTU, second Longin domain
CCZ1/INTU/HPS4, third Longin domain
CCZ1/INTU/HSP4, first Longin domain
PDZ domain
PDZ superfamily
Protein inturned

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050592	asphyxiating thoracic dystrophy	Alliance of Genome Resources
DOID:0080289	orofaciodigital syndrome XVII	Alliance of Genome Resources

Ortholog

Displaying entries **71 - 76** of 76 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Chelonoidis abingdonii	116839817		CHEAB20478
Rhinolophus ferrumequinum	117037409		RHIFE14947
Balaenoptera musculus	118896116		BALMU28539
Panthera leo	122217876		PANLE27560
Ursus americanus	123793295		URSAM14024
Pongo pygmaeus	129035040	9600_0:00155b