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chitinase acidic

Summary

Gene Symbol

CHIA

Aliases

AMCase
CHIT2
TSA1902
acidic mammalian chitinase

Organism

Homo sapiens (human)

External Links

NCBI Gene

27159

HGNC

17432

KEGG Gene ID

hsa:27159

PubChem

27159

Alliance of Genome Resources

HGNC:17432

Annotation

Keyword

3D-structure
Alternative splicing
Apoptosis
Chitin degradation
Chitin-binding
Cytoplasm
Disulfide bond
Glycosidase
Immunity
Inflammatory response
Reference proteome
Secreted
Signal

Proteins

Displaying **all 5** entries
UniProt	Protein Name
A8K3T7
Q2VT96
Q1M0P3
Q9BZP6	Lung-specific protein TSA1902
Q1M0P4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
polysaccharide digestion	TAS
immune system process	IEA
production of molecular mediator involved in inflammatory response	IDA	18824549
polysaccharide catabolic process	IEA
apoptotic process	IEA

GO Hierarchy

biological process

immune system process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

chitin metabolic process

chitin catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process

aminoglycan catabolic process [inference]

chitin catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

amino sugar catabolic process [inference]

glucosamine-containing compound catabolic process [inference]

chitin catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

chitin metabolic process

chitin catabolic process

macromolecule catabolic process [inference]

polysaccharide catabolic process

aminoglycan catabolic process [inference]

chitin catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

chitin metabolic process

chitin catabolic process

amino sugar metabolic process [inference]

amino sugar catabolic process [inference]

glucosamine-containing compound catabolic process [inference]

chitin catabolic process

glucosamine-containing compound metabolic process [inference]

chitin metabolic process

chitin catabolic process

glucosamine-containing compound catabolic process [inference]

chitin catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

amino sugar catabolic process [inference]

glucosamine-containing compound catabolic process [inference]

chitin catabolic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

chitin metabolic process

chitin catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process

aminoglycan catabolic process [inference]

chitin catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

amino sugar catabolic process [inference]

glucosamine-containing compound catabolic process [inference]

chitin catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

multicellular organismal process [inference]

production of molecular mediator involved in inflammatory response

digestion [inference]

polysaccharide digestion

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of chemokine production [inference]

positive regulation of chemokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of chemokine production [inference]

positive regulation of chemokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of chemokine production [inference]

positive regulation of chemokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of chemokine production [inference]

positive regulation of chemokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of chemokine production [inference]

positive regulation of chemokine production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	IBA TAS
cytoplasm	ISS NAS	10548734
extracellular space	IDA	18824549

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
chitin binding	IBA
chitinase activity	IBA IDA NAS TAS	10548734 19435888
kinase binding	IPI	18824549
protein binding	IPI	18824549 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

chitinase activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding

carbohydrate derivative binding [inference]

chitin binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000134216

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K01183

Name

chitinase [EC:3.2.1.14]

References

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:2474	vernal conjunctivitis	DisGeNET
DOID:2841	asthma	DisGeNET DisGeNET DisGeNET Alliance of Genome Resources
DOID:4481	allergic rhinitis	DisGeNET
DOID:4730	vasomotor rhinitis	DisGeNET
DOID:9360	intrinsic asthma	DisGeNET DisGeNET
DOID:9415	allergic asthma	DisGeNET DisGeNET DisGeNET

Ortholog

Displaying entries **11 - 20** of 73 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Lepisosteus oculatus	102691530		LEPOC11666
Danio rerio	337333	ZFIN:ZDB-GENE-030131-9279
Danio rerio	406338	ZFIN:ZDB-GENE-040426-2014
Danio rerio	406819	ZFIN:ZDB-GENE-040426-2891
Astyanax mexicanus	103031188		ASTMX05544
Ictalurus punctatus	108255197		ICTPU16232
Ictalurus punctatus	108255198		ICTPU16232
Electrophorus electricus	113579164		ELEEL22029
Salmo salar	106565087		SALSA24390
Salmo salar	106565088		SALSA24353

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements