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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
glutamate-cysteine ligase catalytic subunit
Summary
- Gene Symbol
-
- GCLC
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- ATP-binding
- Acetylation
- Disease variant
- Glutathione biosynthesis
- Hereditary hemolytic anemia
- Ligase
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to oxidative stress | ||
| negative regulation of apoptotic process | ||
| response to cadmium ion | ||
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process | ||
| response to xenobiotic stimulus |
GO Hierarchy
- response to activity
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
response to endogenous stimulus [inference]
response to chemical [inference]
cellular response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| glutamate-cysteine ligase complex | ||
| cytosol | ||
| mitochondrion |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| magnesium ion binding | ||
| glutamate-cysteine ligase activity | ||
| ATP binding | ||
| protein binding | ||
| protein-containing complex binding |
Disease
- Disease Ontology
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 174438 | WB:WBGene00001527 | ||
| 53581 | FB:FBgn0040319 | ||
| 326857 | ZFIN:ZDB-GENE-030131-5056 | DANRE05984 | |
| 103047245 | ASTMX20456 | ||
| 108263259 | ICTPU27312 | ||
| 113588572 | ELEEL01477 | ||
| 106612605 | SALSA66112 | ||
| 115153437 | SALTR08786 | ||
| 115201609 | SALTR101632 | ||
| 115559885 | GADMO14561 |
