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MIRAGE
glutamate-cysteine ligase catalytic subunit
Summary
- Gene Symbol
-
- GCLC
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- ATP-binding
- Acetylation
- Disease variant
- Glutathione biosynthesis
- Hereditary hemolytic anemia
- Ligase
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to arsenic-containing substance | ||
| cellular response to thyroxine stimulus | ||
| negative regulation of hepatic stellate cell activation | ||
| negative regulation of DNA-templated transcription | ||
| response to heat |
GO Hierarchy
- response to activity
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
response to endogenous stimulus [inference]
response to chemical [inference]
cellular response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytosol | ||
| mitochondrion | ||
| glutamate-cysteine ligase complex |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| ATP binding | ||
| protein binding | ||
| glutamate binding | ||
| protein-containing complex binding | ||
| ADP binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- glutamate cysteine ligase
- Functional Category
-
- E: Amino acid transport and metabolism
- J: Translation, ribosomal structure and biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| catalytic activity |
| glutamate-cysteine ligase activity |
| glutathione biosynthetic process |
| ligase activity |
| nucleotide binding |
| InterPro |
|---|
| Glutamate-cysteine ligase catalytic subunit |
| Glutamine synthetase/guanido kinase, catalytic domain |
Disease
- Disease Ontology
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 14629 | MGI:104990 | MOUSE60656 | ||
| 25283 | RGD:619868 | RATNO41217 | ||
| 53581 | FB:FBgn0040319 | |||
| 174438 | WB:WBGene00001527 | |||
| 326857 | ZFIN:ZDB-GENE-030131-5056 | DANRE05984 | ||
| 512468 | BOVIN18238 | |||
| 609822 | CANLF02862 | |||
| 710508 | MACMU34523 | |||
| 742732 | 9598_0:001ae9 | PANTR38416 | ||
| 780264 | Xenbase:XB-GENE-1002435 |
