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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
glycine decarboxylase
Summary
- Gene Symbol
-
- GLDC
- Aliases
-
- GCSP
- NKH
- glycine cleavage system protein P
- glycine dehydrogenase
- nonketotic hyperglycinemia
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Disease variant
- Mitochondrion
- Oxidoreductase
- Pyridoxal phosphate
- Reference proteome
- Transit peptide
- Proteins
| UniProt | Protein Name |
|---|---|
| P23378 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| glycine decarboxylation via glycine cleavage system | ||
| glycine catabolic process | ||
| response to methylamine | ||
| cellular response to leukemia inhibitory factor | ||
| response to lipoic acid |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
catabolic process [inference]
cellular metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| glycine cleavage complex | ||
| plasma membrane | ||
| mitochondrial matrix |
|
|
| mitochondrion | ||
| nucleoplasm |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| electron transfer activity |
|
|
| lyase activity | ||
| protein homodimerization activity | ||
| pyridoxal phosphate binding | ||
| pyridoxal binding |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0014667 | disease of metabolism | |
| DOID:0050569 | Seckel syndrome | |
| DOID:0050841 | focal hand dystonia | |
| DOID:0060254 | Robinow syndrome | |
| DOID:0060578 | Noonan syndrome 1 | |
| DOID:0060580 | Noonan syndrome 2 | |
| DOID:0060581 | Noonan syndrome 3 | |
| DOID:0060582 | Noonan syndrome 4 | |
| DOID:0060583 | Noonan syndrome 5 | |
| DOID:0060584 | Noonan syndrome 6 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000711 | Restlessness |
| HP:0000718 | Aggressive behavior |
| HP:0000737 | Irritability |
| HP:0000752 | Hyperactivity |
| HP:0001249 | Intellectual disability |
| HP:0001250 | Seizure |
| HP:0001252 | Hypotonia |
| HP:0001254 | Lethargy |
| HP:0001265 | Hyporeflexia |
| Disease ID | Disease Name |
|---|---|
| OMIM:605899 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 174012 | WB:WBGene00020022 | ||
| 41253 | FB:FBgn0037801 | ||
| 100176441 | CIOIN08280 | ||
| 103185467 | CALMI32301 | ||
| 321621 | ZFIN:ZDB-GENE-030131-340 | ||
| 103032063 | ASTMX08610 | ||
| 108255661 | ICTPU17314 | ||
| 113572937 | ELEEL12584 | ||
| 106580033 | SALSA95288 | ||
| 106585394 | SALSA109422 |
