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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
glycine decarboxylase
Summary
- Gene Symbol
-
- GLDC
- Aliases
-
- GCSP
- NKH
- glycine cleavage system protein P
- glycine dehydrogenase
- nonketotic hyperglycinemia
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Disease variant
- Mitochondrion
- Oxidoreductase
- Pyridoxal phosphate
- Reference proteome
- Transit peptide
- Proteins
| UniProt | Protein Name |
|---|---|
| P23378 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| glycine decarboxylation via glycine cleavage system | ||
| glycine catabolic process | ||
| response to methylamine | ||
| cellular response to leukemia inhibitory factor | ||
| response to lipoic acid |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
catabolic process [inference]
cellular metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| glycine cleavage complex | ||
| plasma membrane | ||
| mitochondrial matrix |
|
|
| mitochondrion | ||
| nucleoplasm |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| electron transfer activity |
|
|
| lyase activity | ||
| protein homodimerization activity | ||
| pyridoxal phosphate binding | ||
| pyridoxal binding |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060585 | Noonan syndrome 7 | |
| DOID:0060586 | Noonan syndrome 8 | |
| DOID:0060587 | Noonan syndrome 9 | |
| DOID:0060588 | Noonan syndrome 10 | |
| DOID:0060608 | microcephalic osteodysplastic primordial dwarfism type I | |
| DOID:0060609 | microcephalic osteodysplastic primordial dwarfism type II | |
| DOID:0060644 | chondrodysplasia-pseudohermaphroditism syndrome | |
| DOID:0060672 | Grn-related frontotemporal lobar degeneration with Tdp43 inclusions | |
| DOID:0060732 | chromosome 9p deletion syndrome | |
| DOID:0060764 | autosomal recessive Robinow syndrome |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000711 | Restlessness |
| HP:0000718 | Aggressive behavior |
| HP:0000737 | Irritability |
| HP:0000752 | Hyperactivity |
| HP:0001249 | Intellectual disability |
| HP:0001250 | Seizure |
| HP:0001252 | Hypotonia |
| HP:0001254 | Lethargy |
| HP:0001265 | Hyporeflexia |
| Disease ID | Disease Name |
|---|---|
| OMIM:605899 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 464987 | PANTR43625 | ||
| 100452822 | PONAB35396 | ||
| 129047248 | PONAB35396 | ||
| 481534 | CANLF02169 | ||
| 112921980 | VULVU14919 | ||
| 123781287 | URSAM20364 | ||
| 100472555 | AILME02647 | ||
| 101680781 | MUSPF02140 | ||
| 101100163 | FELCA30292 | ||
| 122205283 | PANLE25249 |
