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DNA polymerase lambda

Summary

Gene Symbol

POLL

Organism

Homo sapiens (human)

External Links

NCBI Gene

27343

PubChem

27343

Alliance of Genome Resources

HGNC:9184

Annotation

Keyword

3D-structure
Alternative splicing
Chromosome
DNA repair
DNA replication
DNA synthesis
DNA-binding
DNA-directed DNA polymerase
Lyase
Manganese
Metal-binding
Nucleus
Proteomics identification
Reference proteome

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q5JQP8
A8K860
B4DE17
Q9UGP5	DNA polymerase beta-2 DNA polymerase kappa

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
double-strand break repair via homologous recombination	IMP	20693240
DNA replication	NAS	10982892
base-excision repair, gap-filling	IDA	19806195
nucleotide-excision repair	IDA	10982892
double-strand break repair via nonhomologous end joining	TAS

GO Hierarchy

biological process

immune system process [inference]

somatic diversification of immune receptors [inference]

somatic diversification of immune receptors via somatic mutation [inference]

somatic hypermutation of immunoglobulin genes

somatic diversification of immunoglobulins [inference]

somatic hypermutation of immunoglobulin genes

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

double-strand break repair [inference]

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

double-strand break repair [inference]

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

double-strand break repair [inference]

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

double-strand break repair [inference]

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

double-strand break repair [inference]

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA biosynthetic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

double-strand break repair [inference]

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA biosynthetic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

double-strand break repair [inference]

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

double-strand break repair [inference]

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

double-strand break repair [inference]

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

double-strand break repair [inference]

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

double-strand break repair [inference]

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

double-strand break repair [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

double-strand break repair [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleus	NAS	10982892
nucleus	IBA
nucleoplasm	TAS
nucleoplasm	IDA
site of double-strand break	IDA	30250067

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

site of DNA damage [inference]

site of double-strand break

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
DNA binding	NAS	10982892
DNA-directed DNA polymerase activity	NAS	10982892
DNA-directed DNA polymerase activity	TAS
DNA-directed DNA polymerase activity	IDA	19806195
DNA-directed DNA polymerase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

DNA polymerase activity [inference]

DNA-directed DNA polymerase activity

lyase activity [inference]

carbon-oxygen lyase activity [inference]

5'-deoxyribose-5-phosphate lyase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA polymerase activity [inference]

DNA-directed DNA polymerase activity

5'-deoxyribose-5-phosphate lyase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dna polymerase

Functional Category

E: Amino acid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
DNA biosynthetic process
DNA polymerase activity
DNA repair
double-strand break repair via nonhomologous end joining
nucleotidyltransferase activity
transferase activity

Displaying **all 10** entries
InterPro
DNA polymerase beta, palm domain
DNA polymerase beta, thumb domain
DNA polymerase beta-like, N-terminal domain
DNA polymerase family X, beta-like
DNA polymerase family X
DNA polymerase lambda lyase domain superfamily
DNA polymerase lambda, fingers domain
DNA polymerase, thumb domain superfamily
DNA-directed DNA polymerase X
Nucleotidyltransferase superfamily

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements