GlyCosmos Portal

Annotation

Keyword

3D-structure
ADP-ribosylation
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A142FHB8
P43220

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
hormone secretion	IEA
cAMP-mediated signaling	IDA	7589461
regulation of heart contraction	IEA
post-translational protein targeting to membrane, translocation	IEA
negative regulation of blood pressure	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cAMP-mediated signaling

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

transmembrane transport [inference]

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

behavior [inference]

learning or memory

response to stimulus [inference]

response to stress [inference]

response to psychosocial stress

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

response to peptide hormone [inference]

response to glucagon [inference]

cellular response to glucagon stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

response to peptide hormone [inference]

response to glucagon [inference]

cellular response to glucagon stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

response to peptide [inference]

response to peptide hormone [inference]

response to glucagon [inference]

cellular response to glucagon stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

response to peptide [inference]

response to peptide hormone [inference]

response to glucagon [inference]

cellular response to glucagon stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to glucagon [inference]

cellular response to glucagon stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

establishment of localization [inference]

transport [inference]

hormone transport [inference]

hormone secretion

secretion [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

transmembrane transport [inference]

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cAMP-mediated signaling

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

regulation of blood pressure [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

regulation of catalytic activity [inference]

regulation of cyclase activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

regulation of adenylate cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

positive regulation of catalytic activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

regulation of lyase activity [inference]

regulation of adenylate cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane	TAS	8405712
plasma membrane	IBA IDA TAS	28514449

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25416956 32296183
peptide hormone binding	IBA
glucagon receptor activity	IBA
glucagon-like peptide 1 receptor activity	IBA IDA	28514449
transmembrane signaling receptor activity	TAS	8405712

GO Hierarchy

molecular function

binding [inference]

protein binding

amide binding [inference]

peptide binding [inference]

peptide hormone binding

hormone binding [inference]

peptide hormone binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

transmembrane signaling receptor activity

G protein-coupled receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

growth hormone releasing hormone receptor a

Functional Category

I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
G protein-coupled peptide receptor activity
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
cell surface receptor signaling pathway
peptide hormone binding

Displaying **all 5** entries
InterPro
GPCR family 2, extracellular hormone receptor domain superfamily
GPCR, family 2, extracellular hormone receptor domain
GPCR, family 2, secretin-like, conserved site
GPCR, family 2, secretin-like
GPCR, family 2-like, 7TM

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:10763	hypertension	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:4195	hyperglycemia	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 56 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	14652		MGI:99571	MOUSE22739
Rattus norvegicus	25051		RGD:2703	RATNO22352
Drosophila melanogaster	31234		FB:FBgn0260753
Caenorhabditis elegans	191374		WB:WBGene00014035
Pan troglodytes	472001	9598_0:001cf8		PANTR38084
Ovis aries	541609			SHEEP10234
Danio rerio	562973		ZFIN:ZDB-GENE-050516-1
Danio rerio	565237		ZFIN:ZDB-GENE-050516-2
Macaca mulatta	719548			MACMU35436
Monodelphis domestica	100026886			MONDO11935

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements