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Guidelines

MIRAGE

ATP-binding cassette, sub-family A member 7

Summary

Gene Symbol

Abca7

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

27403

PubChem

27403

Alliance of Genome Resources

MGI:1351646

Annotation

Keyword

ATP-binding
Cell membrane
Cell projection
Cytoplasm
Disulfide bond
Endosome
Glycoprotein
Golgi apparatus
Lipid transport
Phagocytosis
Proteomics identification
Reference proteome
Repeat
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q91V24
E9Q6G4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 39 in total

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GO Term	Evidence Code	PMID
phagocytosis	IEA
memory	IMP	23467355
visual learning	IMP	27030769
positive regulation of cholesterol efflux	IDA	18429932
peptide cross-linking	IDA	12917409

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process [inference]

amyloid-beta formation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process [inference]

amyloid-beta formation

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process [inference]

amyloid-beta formation

catabolic process [inference]

cellular catabolic process [inference]

amyloid-beta clearance by cellular catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

amyloid-beta clearance by cellular catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process [inference]

amyloid-beta formation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process [inference]

amyloid-beta formation

macromolecule modification [inference]

protein modification process [inference]

peptide cross-linking

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process [inference]

amyloid-beta formation

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process [inference]

amyloid-beta formation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

apolipoprotein A-I-mediated signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

cellular metabolic process [inference]

cellular catabolic process [inference]

amyloid-beta clearance by cellular catabolic process

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus

transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

protein-lipid complex organization [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

membrane organization [inference]

membrane raft organization [inference]

plasma membrane raft organization

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

memory

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

memory

visual behavior [inference]

visual learning

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

amyloid-beta clearance [inference]

amyloid-beta clearance by cellular catabolic process

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

transmembrane transport

organic substance transport [inference]

lipid transport [inference]

phospholipid transport [inference]

sterol transport [inference]

cholesterol transport [inference]

cholesterol efflux

lipid translocation [inference]

phospholipid translocation

organophosphate ester transport [inference]

phospholipid transport [inference]

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

cholesterol efflux

import into cell [inference]

endocytosis [inference]

phagocytosis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of amyloid-beta formation

regulation of amyloid-beta formation [inference]

negative regulation of amyloid-beta formation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein catabolic process

regulation of amyloid-beta formation [inference]

negative regulation of amyloid-beta formation

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein catabolic process

regulation of amyloid-beta formation [inference]

negative regulation of amyloid-beta formation

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein catabolic process

regulation of amyloid-beta formation [inference]

negative regulation of amyloid-beta formation

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of PERK-mediated unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid efflux

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of cholesterol transport [inference]

regulation of cholesterol efflux [inference]

positive regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of phospholipid transport [inference]

regulation of phospholipid efflux [inference]

positive regulation of phospholipid efflux

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid efflux

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid efflux

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of phagocytosis, engulfment [inference]

positive regulation of engulfment of apoptotic cell

positive regulation of apoptotic cell clearance [inference]

positive regulation of engulfment of apoptotic cell

negative regulation of transport [inference]

negative regulation of endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of phagocytosis, engulfment [inference]

positive regulation of engulfment of apoptotic cell

positive regulation of apoptotic cell clearance [inference]

positive regulation of engulfment of apoptotic cell

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of phagocytosis, engulfment [inference]

positive regulation of engulfment of apoptotic cell

positive regulation of apoptotic cell clearance [inference]

positive regulation of engulfment of apoptotic cell

regulation of phagocytosis, engulfment [inference]

positive regulation of phagocytosis, engulfment [inference]

positive regulation of engulfment of apoptotic cell

regulation of engulfment of apoptotic cell [inference]

positive regulation of engulfment of apoptotic cell

regulation of apoptotic cell clearance [inference]

positive regulation of apoptotic cell clearance [inference]

positive regulation of engulfment of apoptotic cell

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell surface

regulation of protein localization to cell surface [inference]

positive regulation of protein localization to cell surface

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid efflux

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of cholesterol transport [inference]

regulation of cholesterol efflux [inference]

positive regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of phospholipid transport [inference]

regulation of phospholipid efflux [inference]

positive regulation of phospholipid efflux

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid efflux

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid efflux

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of phagocytosis, engulfment [inference]

positive regulation of engulfment of apoptotic cell

positive regulation of apoptotic cell clearance [inference]

positive regulation of engulfment of apoptotic cell

positive regulation of membrane invagination [inference]

positive regulation of phagocytosis, engulfment [inference]

positive regulation of engulfment of apoptotic cell

positive regulation of protein localization [inference]

positive regulation of protein localization to cell surface

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid efflux

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of phagocytosis, engulfment [inference]

positive regulation of engulfment of apoptotic cell

positive regulation of apoptotic cell clearance [inference]

positive regulation of engulfment of apoptotic cell

positive regulation of multicellular organismal process [inference]

positive regulation of amyloid-beta clearance

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid efflux

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of cellular component organization [inference]

negative regulation of endocytosis

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of transport [inference]

negative regulation of endocytosis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of PERK-mediated unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of PERK-mediated unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

apolipoprotein A-I-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of PERK-mediated unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of phagocytosis, engulfment [inference]

positive regulation of engulfment of apoptotic cell

positive regulation of apoptotic cell clearance [inference]

positive regulation of engulfment of apoptotic cell

positive regulation of membrane invagination [inference]

positive regulation of phagocytosis, engulfment [inference]

positive regulation of engulfment of apoptotic cell

positive regulation of protein localization [inference]

positive regulation of protein localization to cell surface

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of cellular component organization [inference]

negative regulation of endocytosis

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of phagocytosis, engulfment [inference]

positive regulation of engulfment of apoptotic cell

positive regulation of apoptotic cell clearance [inference]

positive regulation of engulfment of apoptotic cell

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of phagocytosis, engulfment [inference]

positive regulation of engulfment of apoptotic cell

positive regulation of apoptotic cell clearance [inference]

positive regulation of engulfment of apoptotic cell

regulation of phagocytosis, engulfment [inference]

positive regulation of phagocytosis, engulfment [inference]

positive regulation of engulfment of apoptotic cell

regulation of engulfment of apoptotic cell [inference]

positive regulation of engulfment of apoptotic cell

regulation of apoptotic cell clearance [inference]

positive regulation of apoptotic cell clearance [inference]

positive regulation of engulfment of apoptotic cell

negative regulation of cellular component organization [inference]

negative regulation of endocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of phagocytosis, engulfment [inference]

positive regulation of engulfment of apoptotic cell

positive regulation of apoptotic cell clearance [inference]

positive regulation of engulfment of apoptotic cell

positive regulation of membrane invagination [inference]

positive regulation of phagocytosis, engulfment [inference]

positive regulation of engulfment of apoptotic cell

regulation of membrane invagination [inference]

regulation of phagocytosis, engulfment [inference]

positive regulation of phagocytosis, engulfment [inference]

positive regulation of engulfment of apoptotic cell

regulation of engulfment of apoptotic cell [inference]

positive regulation of engulfment of apoptotic cell

positive regulation of membrane invagination [inference]

positive regulation of phagocytosis, engulfment [inference]

positive regulation of engulfment of apoptotic cell

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell surface

regulation of protein localization to cell surface [inference]

positive regulation of protein localization to cell surface

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of phagocytosis, engulfment [inference]

positive regulation of engulfment of apoptotic cell

positive regulation of apoptotic cell clearance [inference]

positive regulation of engulfment of apoptotic cell

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of phagocytosis, engulfment [inference]

positive regulation of engulfment of apoptotic cell

positive regulation of apoptotic cell clearance [inference]

positive regulation of engulfment of apoptotic cell

regulation of phagocytosis, engulfment [inference]

positive regulation of phagocytosis, engulfment [inference]

positive regulation of engulfment of apoptotic cell

regulation of engulfment of apoptotic cell [inference]

positive regulation of engulfment of apoptotic cell

regulation of apoptotic cell clearance [inference]

positive regulation of apoptotic cell clearance [inference]

positive regulation of engulfment of apoptotic cell

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of PERK-mediated unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of amyloid-beta clearance

regulation of amyloid-beta clearance [inference]

positive regulation of amyloid-beta clearance

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
Golgi membrane	IEA
phagocytic cup	IDA	16908670
intracellular anatomical structure	IDA	15520449
cytoplasm	IDA	27472885
Golgi apparatus	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

bounding membrane of organelle [inference]

Golgi membrane

endosome membrane [inference]

early endosome membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

ruffle membrane

cell junction

leading edge membrane [inference]

ruffle membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

glial cell projection

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle

Golgi apparatus

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	12917409
ATP binding	IEA
phospholipid transporter activity	ISO
phospholipid transporter activity	IDA	15520449
ATP hydrolysis activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity [inference]

phospholipid transporter activity

phosphatidylcholine transporter activity [inference]

phosphatidylcholine floppase activity

phosphatidylserine floppase activity

intramembrane lipid transporter activity [inference]

ATPase-coupled intramembrane lipid transporter activity [inference]

floppase activity

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

cargo receptor activity [inference]

apolipoprotein receptor activity [inference]

apolipoprotein A-I receptor activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

apolipoprotein A-I receptor activity

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

ATPase-coupled intramembrane lipid transporter activity [inference]

floppase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

atp-binding cassette sub-family a

Functional Category

G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter A
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
ABC-2 type transporter, transmembrane domain
P-loop containing nucleoside triphosphate hydrolase

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026