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Guidelines

MIRAGE

piccolo presynaptic cytomatrix protein

Summary

Gene Symbol

PCLO

Organism

Homo sapiens (human)

External Links

NCBI Gene

27445

PubChem

27445

Alliance of Genome Resources

HGNC:13406

Annotation

Keyword

3D-structure
Alternative splicing
Calcium/phospholipid-binding
Cell projection
Neurodegeneration
Phosphoprotein
Reference proteome
Repeat
Synapse
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y6V0	Aczonin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cytoskeleton organization	ISS
synaptic vesicle exocytosis	NAS	10508862
regulation of exocytosis	IEA
insulin secretion	IEA
protein localization to synapse	IBA

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis

actin filament-based process [inference]

actin cytoskeleton organization [inference]

presynaptic actin cytoskeleton organization

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to cell junction [inference]

protein localization to synapse

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

actin cytoskeleton organization [inference]

presynaptic actin cytoskeleton organization

presynaptic cytoskeleton organization [inference]

presynaptic actin cytoskeleton organization

cellular component assembly [inference]

presynaptic active zone assembly

cell junction organization [inference]

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of presynaptic active zone structure

synapse organization [inference]

maintenance of synapse structure [inference]

maintenance of presynaptic active zone structure

cellular component maintenance [inference]

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of presynaptic active zone structure

presynaptic active zone organization [inference]

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

signal release from synapse [inference]

synaptic vesicle exocytosis

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to cell junction [inference]

protein localization to synapse

establishment of localization [inference]

transport [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis

secretion [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

signal release from synapse [inference]

synaptic vesicle exocytosis

organic substance transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

nitrogen compound transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

amide transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

signal release from synapse [inference]

synaptic vesicle exocytosis

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

establishment of localization in cell [inference]

synaptic vesicle exocytosis

organelle localization [inference]

vesicle localization [inference]

synaptic vesicle localization [inference]

synaptic vesicle clustering

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to cell junction [inference]

protein localization to synapse

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of exocytosis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis

regulation of cellular process [inference]

regulation of vesicle-mediated transport [inference]

regulation of exocytosis

regulation of secretion by cell [inference]

regulation of exocytosis

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cytoskeleton	NAS	10508862
postsynaptic density	IEA
axon	IBA
synapse	ISS
cytoskeleton of presynaptic active zone	TAS	15217342

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell junction [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cortical cytoskeleton [inference]

cytoskeleton of presynaptic active zone

presynaptic cytoskeleton [inference]

cytoskeleton of presynaptic active zone

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cortical cytoskeleton [inference]

cytoskeleton of presynaptic active zone

presynaptic cytoskeleton [inference]

cytoskeleton of presynaptic active zone

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

postsynaptic specialization [inference]

postsynaptic density

Displaying **all 5** entries
GO Term	Evidence Code	PMID
calcium ion binding	ISS
profilin binding	ISS
calcium-dependent phospholipid binding	ISS
zinc ion binding	IEA
structural constituent of presynaptic active zone	IBA

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of synapse [inference]

structural constituent of presynaptic active zone

binding [inference]

protein binding [inference]

profilin binding

lipid binding [inference]

phospholipid binding [inference]

calcium-dependent phospholipid binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

C2 domain-containing protein protein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
C2 domain superfamily
C2 domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060272	pontocerebellar hypoplasia type 3	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 29 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	8927	WB:WBGene00018468
Caenorhabditis elegans	12217	WB:WBGene00018468
Mus musculus	26875	ZFIN:ZDB-GENE-030131-8100	MOUSE44506
Xenopus laevis	27445	Xenbase:XB-GENE-17344762
Rattus norvegicus	56768	ZFIN:ZDB-GENE-030131-8100	RATNO30495
Pan troglodytes	463505		PANTR40649
Canis lupus familiaris	483388		CANLF05579
Macaca mulatta	708685		MACMU32172
Ornithorhynchus anatinus	100074697		ORNAN05144
Taeniopygia guttata	100217797		TAEGU08619

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

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Last updated: April 7, 2025