GlyCosmos Portal

GlyTouCan

Glycan Structure Repository

GlyComb

Glycoconjugate Repository

GlycoPOST

Glycomics MS raw data Repository

UniCarb-DR

Glycomics MS Repository for glycan annotations from GlycoWorkbench

All Resources

Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms

Other Information

Release Statistics Download

Tools

Glycan Converters

LM-GlycomeAtlas

Search Tools

Cross Search Glycan Search Publication Search Programmatic Access

GDP-mannose 4,6-dehydratase

Summary

Gene Symbol

GMDS

Aliases

GMD
SDR3E1
short chain dehydrogenase/reductase family 3E, member 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

2762

HGNC

4369

KEGG Gene ID

hsa:2762

PubChem

2762

Alliance of Genome Resources

HGNC:4369

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Lyase
NADP
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
O60547	GDP-D-mannose dehydratase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
'de novo' GDP-L-fucose biosynthetic process	IBA IDA IEA	9525924
Notch signaling pathway	ISS
GDP-mannose metabolic process	IBA IDA IGI	9525924 9603974

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

GDP-mannose metabolic process

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

GDP-mannose metabolic process

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

phosphorus metabolic process [inference]

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

GDP-mannose metabolic process

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

GDP-mannose metabolic process

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

GDP-mannose metabolic process

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

GDP-mannose metabolic process

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

organic substance metabolic process [inference]

carbohydrate derivative metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

GDP-mannose metabolic process

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

GDP-mannose metabolic process

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

GDP-mannose metabolic process

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

phosphorus metabolic process [inference]

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

GDP-mannose metabolic process

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

GDP-mannose metabolic process

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

'de novo' GDP-L-fucose biosynthetic process

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytosol
cytoplasm	IBA IC	9525924
extracellular exosome	HDA	19199708

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
GDP-mannose 4,6-dehydratase activity	IBA IDA IGI TAS	9525924 9603974
NADP+ binding	IDA	9525924
protein binding	IPI	25416956 32296183
identical protein binding	IPI	16189514 25416956 31515488 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-oxygen lyase activity [inference]

hydro-lyase activity [inference]

GDP-mannose 4,6-dehydratase activity

binding [inference]

protein binding

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding [inference]

NADP+ binding

ion binding [inference]

anion binding [inference]

NADP+ binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding [inference]

NADP+ binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000112699

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K01711

Name

GDPmannose 4,6-dehydratase [EC:4.2.1.47]

References

Rhea

GDP-α-D-mannose

H₂O + GDP-4-dehydro-α-D-rhamnose

Enzyme

4.2.1.47

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 25 in total

1

2

3

Next ›

Last »
DO ID	Disease Name	Source
DOID:0070255	congenital disorder of glycosylation type IIc	Alliance of Genome Resources
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:1067	open-angle glaucoma	DisGeNET Alliance of Genome Resources
DOID:1070	primary open angle glaucoma	DisGeNET DisGeNET
DOID:10965	spastic diplegia	DisGeNET
DOID:10968	spastic monoplegia	DisGeNET
DOID:10969	hemiplegia	DisGeNET
DOID:10970	spastic quadriplegic cerebral palsy	DisGeNET
DOID:12849	autistic disorder	DisGeNET
DOID:1324	lung cancer	DisGeNET

Ortholog

Displaying entries **1 - 10** of 68 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	177717	WB:WBGene00000266
Caenorhabditis elegans	186416	WB:WBGene00010166
Drosophila melanogaster	33716	FB:FBgn0031661
Callorhinchus milii	103188644		CALMI39563
Danio rerio	393461	ZFIN:ZDB-GENE-050419-45	DANRE18695
Ictalurus punctatus	108257898		ICTPU20659
Electrophorus electricus	113570487		ELEEL07731
Salmo salar	100196344		SALSA50047
Gadus morhua	115555735		GADMO07249
Oreochromis niloticus	100700141		ORENI23564

About Release Notes Help Feedback

Click here to visit the beta site.

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

Logo License Policies Site Map

Contact: support@glycosmos.org

GlyCosmos Portal v4.0.0

Last updated: August 19, 2024