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fucosyltransferase 2 (H blood group)

Summary

Gene Symbol

FUT2

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 281175
KEGG Gene ID: bta:281175
PubChem: 281175

Annotation

Keyword

Glycoprotein
Glycosyltransferase
Golgi apparatus
Lipid metabolism
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
F1MUS1
Q28113	Alpha(1,2)FT 2 Fucosyltransferase 2 GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2 Secretor factor Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2 Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
regulation of cell adhesion
fucosylation	IEA	30032202
protein glycosylation	IEA	30032202
regulation of endothelial cell proliferation
carbohydrate metabolic process	IEA	22301074 30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process

primary metabolic process [inference]

carbohydrate metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

glycosylation [inference]

fucosylation

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

carbohydrate derivative metabolic process [inference]

liposaccharide metabolic process [inference]

glycolipid metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

cellular process [inference]

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cell adhesion

regulation of cell population proliferation [inference]

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane	IEA	22301074 30032202
Golgi cisterna membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

Golgi cisterna membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
galactoside 2-alpha-L-fucosyltransferase activity	IEA	22301074 30032202
alpha-(1,2)-fucosyltransferase activity

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

fucosyltransferase activity [inference]

alpha-(1,2)-fucosyltransferase activity

galactoside 2-alpha-L-fucosyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Galactoside 2-alpha-L-fucosyltransferase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
fucosylation
galactoside 2-alpha-L-fucosyltransferase activity
transferase activity

Displaying 1 entry
InterPro
Glycosyl transferase, family 11

KEGG BRITE Database

Orthology

K00718

Name

galactoside 2-L-fucosyltransferase 1/2 [EC:2.4.1.69]

References

Reactions

Displaying entries **1 - 10** of 12 in total

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KEGG Reaction	Enzyme	Acceptor	Product
R06086	2.4.1.69	G98900YM	G87164WU
R06156	2.4.1.69	G00049MO	G00050MO
R06170	2.4.1.69	G56390QA	G63238VS
R06089	2.4.1.69	G98726UE	G28261RX
R05968	2.4.1.69	G99053DY	G98465JN
R06027	2.4.1.-	G60645OK	G77593JU
R06090	2.4.1.69	G28261RX	G87164WU
R06024	2.4.1.69	G58896AZ	G13636IT
R06035	2.4.1.69	G84034JH	G66427ZQ
R06031	2.4.1.69	G64885AH	G58990QD

Rhea

RHEA:50664

a β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl derivative + GDP-β-L-fucose

an α-L-Fuc-(1→2)-β-D-Gal-(1→3)-β-D-GlcNAc derivative + H⁺ + GDP

Enzyme

2.4.1.69

PMID

RHEA:32175

a β-D-Gal-(1→3)-β-D-GlcNAc-(1→3)-β-D-Gal-(1→4)-β-D-Glc-(1↔1ʼ)-Cer(d18:1(4E)) + GDP-β-L-fucose

H⁺ + α-L-fucosyl-(1→2)- β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1ʼ)-N-acylsphing-4-enine + GDP

Enzyme

2.4.1.69

PMID

RHEA:50668

a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + GDP-β-L-fucose

an α-L-Fuc-(1→2)-β-D-Gal-(1→4)-β-D-GlcNAc derivative + H⁺ + GDP

Enzyme

2.4.1.344

PMID

Ortholog

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	2524	HUMAN44855
Mus musculus	14344	MOUSE55044
Mus musculus	56546	MOUSE55046
Rattus norvegicus	58924	RATNO17365
Rattus norvegicus	308586	RATNO17426
Sus scrofa	397139	PIGXX28198
Pan troglodytes	468944	PANTR18844
Macaca mulatta	722582	MACMU18062
Monodelphis domestica	100009916	MONDO18716
Equus caballus	100054259	HORSE01005

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements