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gamma-aminobutyric acid type A receptor subunit alpha4

Summary

Gene Symbol

GABRA4

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 282238
PubChem: 282238

Annotation

Keyword

Cell membrane
Chloride channel
Disulfide bond
Glycoprotein
Ligand-gated ion channel
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P20237	GABA(A) receptor subunit alpha-4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
signal transduction	IEA	30032202
gamma-aminobutyric acid signaling pathway	IEA	22301074 30032202
nervous system process	IEA	30032202
synaptic transmission, GABAergic	IEA	30032202
regulation of postsynaptic membrane potential	IEA	30032202

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

signal transduction

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly [inference]

inhibitory synapse assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly [inference]

inhibitory synapse assembly

synapse organization [inference]

synapse assembly [inference]

inhibitory synapse assembly

multicellular organismal process [inference]

system process [inference]

nervous system process

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

regulation of cellular process [inference]

signal transduction

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
plasma membrane	IEA	30032202
dendrite membrane	IEA	30032202
chloride channel complex
neuron projection	IEA	30032202
synapse	IEA	30032202

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

GABA receptor complex [inference]

GABA-A receptor complex

membrane protein complex [inference]

transmembrane transporter complex

monoatomic ion channel complex [inference]

chloride channel complex

transporter complex [inference]

transmembrane transporter complex

monoatomic ion channel complex [inference]

chloride channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

dendrite membrane

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse

leading edge membrane [inference]

neuron projection membrane [inference]

dendrite membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

postsynapse

Displaying **all 4** entries
GO Term	Evidence Code	PMID
GABA-A receptor activity	IEA	22301074 30032202
inhibitory extracellular ligand-gated monoatomic ion channel activity	IEA	30032202
benzodiazepine receptor activity	IEA	30032202
GABA-gated chloride ion channel activity	IEA	30032202

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity [inference]

GABA-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

inhibitory extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

GABA-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity [inference]

GABA-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity [inference]

GABA-gated chloride ion channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity [inference]

GABA-gated chloride ion channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity [inference]

GABA-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

inhibitory extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

GABA-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

inhibitory extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

GABA-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

GABA-gated chloride ion channel activity

salt transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity [inference]

GABA-gated chloride ion channel activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

GABA receptor activity [inference]

GABA-A receptor activity

neurotransmitter receptor activity [inference]

benzodiazepine receptor activity

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

GABA-gated chloride ion channel activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

gamma-aminobutyric acid receptor subunit gamma

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying entries **1 - 10** of 14 in total

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Gene Ontology
GABA-A receptor activity
GABA-gated chloride ion channel activity
benzodiazepine receptor activity
chloride channel activity
chloride transmembrane transport
chloride transport
extracellular ligand-gated monoatomic ion channel activity
gamma-aminobutyric acid signaling pathway
inhibitory extracellular ligand-gated monoatomic ion channel activity
monoatomic ion channel activity

Displaying **all 8** entries
InterPro
Gamma-aminobutyric acid A receptor/Glycine receptor alpha
Neuronal acetylcholine receptor
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain superfamily
Neurotransmitter-gated ion-channel transmembrane domain
Neurotransmitter-gated ion-channel, conserved site
Neurotransmitter-gated ion-channel

Ortholog

Displaying entries **1 - 10** of 59 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	2557	HUMAN75448
Mus musculus	14397	MOUSE43375
Rattus norvegicus	140675	RATNO08365
Pan troglodytes	471392	PANTR34035
Canis lupus familiaris	482132	CANLF03365
Macaca mulatta	704008	MACMU37412
Monodelphis domestica	100019555	MONDO27808
Equus caballus	100054615	HORSE30366
Taeniopygia guttata	100232833	TAEGU23195
Oryctolagus cuniculus	100339882	RABIT08040