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ADAM metallopeptidase with thrombospondin type 1 motif 2

Summary

Gene Symbol

ADAMTS2

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 282401
PubChem: 282401

Annotation

Keyword

Cleavage on pair of basic residues
Collagen degradation
Direct protein sequencing
Disulfide bond
Extracellular matrix
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Repeat
Signal
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P79331	Procollagen I N-proteinase Procollagen I/II amino propeptide-processing enzyme Procollagen N-endopeptidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
proteolysis	IEA	22301074
collagen biosynthetic process
collagen fibril organization
collagen catabolic process
extracellular matrix organization	IEA	22301074 30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

catabolic process [inference]

collagen catabolic process

biosynthetic process [inference]

collagen biosynthetic process

collagen metabolic process [inference]

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization

collagen fibril organization

supramolecular fiber organization

collagen fibril organization

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular matrix
collagen-containing extracellular matrix	IEA	22301074
extracellular region

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

Displaying **all 2** entries
GO Term	Evidence Code	PMID
zinc ion binding	IEA	22301074
metalloendopeptidase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

A disintegrin and metalloproteinase with thrombospondin motifs

Functional Category

O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
extracellular matrix organization
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 8** entries
InterPro
ADAMTS, cysteine-rich domain 2
ADAMTS/ADAMTS-like, Spacer 1
ADAMTS/ADAMTS-like, cysteine-rich domain 3
ADAMTS/ADAMTS-like
Metallopeptidase, catalytic domain superfamily
Peptidase M12B, ADAM/reprolysin
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat

Ortholog

Displaying entries **1 - 10** of 65 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Homo sapiens	9509		HUMAN82655
Mus musculus	216725		MOUSE04817
Rattus norvegicus	287899		RATNO01803
Pan troglodytes	462325		PANTR37001
Canis lupus familiaris	481453		CANLF01981
Monodelphis domestica	100029340		MONDO09178
Taeniopygia guttata	100224296		TAEGU04132
Callithrix jacchus	100395899		CALJA26948
Pongo abelii	100447800		PONAB29254
Sus scrofa	100521434	9823_0:000af3	PIGXX19106