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collagen triple helix repeat containing 1

Summary

Gene Symbol

Cthrc1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

282836

PubChem

282836

Alliance of Genome Resources

RGD:628801

Annotation

Keyword

Collagen
Extracellular matrix
Glycoprotein
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8CG08

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
osteoblast proliferation	IEA ISO
negative regulation of canonical Wnt signaling pathway	IEA ISO
cell migration	IMP	15618538
positive regulation of osteoblast proliferation	IEA ISO
Wnt signaling pathway, planar cell polarity pathway	IEA ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway [inference]

Wnt signaling pathway, planar cell polarity pathway

cell population proliferation [inference]

osteoblast proliferation

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

cell motility [inference]

cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

inner ear receptor cell stereocilium organization

multicellular organismal process [inference]

ossification [inference]

ossification involved in bone remodeling

developmental process [inference]

anatomical structure morphogenesis [inference]

establishment of tissue polarity [inference]

establishment of planar polarity [inference]

establishment of planar polarity of embryonic epithelium [inference]

establishment of planar polarity involved in neural tube closure

embryonic morphogenesis [inference]

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of osteoblast proliferation

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

regulation of osteoblast differentiation [inference]

positive regulation of osteoblast differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway [inference]

Wnt signaling pathway, planar cell polarity pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of osteoblast proliferation

regulation of osteoblast proliferation [inference]

positive regulation of osteoblast proliferation

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

regulation of osteoblast differentiation [inference]

positive regulation of osteoblast differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of osteoblast proliferation

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular matrix	IDA	15618538
collagen trimer	IEA
sarcoplasm	IEA ISO
extracellular space	IEA ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

collagen trimer

cellular anatomical entity [inference]

extracellular space

cytoplasm [inference]

sarcoplasm

external encapsulating structure [inference]

extracellular matrix

Displaying **all 2** entries
GO Term	Evidence Code	PMID
frizzled binding	IEA ISO
Wnt-protein binding	IEA ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

frizzled binding

Wnt-protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

collagen triple helix repeat-containing protein 1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 10** entries
Gene Ontology
Wnt signaling pathway, planar cell polarity pathway
Wnt-protein binding
cochlea morphogenesis
establishment of planar polarity involved in neural tube closure
inner ear receptor cell stereocilium organization
ossification involved in bone remodeling
osteoblast differentiation
osteoblast proliferation
positive regulation of osteoblast differentiation
positive regulation of osteoblast proliferation

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9206	Barrett's esophagus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 45 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Mus musculus	68588	10090_1:0047c6	MGI:1915838
Homo sapiens	115908		HGNC:18831
Danio rerio	445308		ZFIN:ZDB-GENE-040808-22
Xenopus tropicalis	548356		Xenbase:XB-GENE-980161
Danio rerio	566140		ZFIN:ZDB-GENE-050420-46
Cavia porcellus	100719188	10141_0:004d4c
Octodon degus	101584484	10160_0:003b6d
Jaculus jaculus	101602028	51337_0:00103b
Heterocephalus glaber	101723358	10181_0:001e5b
Mesocricetus auratus	101840182	10036_0:0038a9