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beta-1,4-N-acetyl-galactosaminyltransferase 3

Summary

Gene Symbol

B4GALNT3

Aliases

B4GalNac-T3
FLJ16224
FLJ40362

Organism

Homo sapiens (human)

External Links

NCBI Gene

283358

GGDB ID

gg106

HGNC

24137

mRNA

NM_173593

map

12p13.33

Protein

NP_775864

OMIM

612220

KEGG Gene ID

hsa:283358

PubChem

283358

Alliance of Genome Resources

HGNC:24137

Annotation

Keyword

Glycosyltransferase
Golgi apparatus
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6L9W6	Beta-1,4-N-acetylgalactosaminyltransferase III N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2
Q8N9V0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IDA
Golgi apparatus	IDA
Golgi cisterna membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

Golgi cisterna membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle

Golgi apparatus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
acetylgalactosaminyltransferase activity	IBA IDA	12966086
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylgalactosaminyltransferase activity

N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity

hexosyltransferase activity [inference]

acetylgalactosaminyltransferase activity

N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000139044

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg106

Gene Symbol

B4GALNT3

Reactions

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-GalNAc	G49108TO	G00057MO	12966086

Displaying **all 4** entries
Donor	Acceptor	Product	Reference
UDP-GalNAc	G49108TO	G00057MO	12966086
UDP-GalNAc	G00035MO	G35179MW	12966086
UDP-GalNAc	G00041MO	G45849QU	12966086
UDP-GalNAc	G00033MO	G52144RR	12966086

Displaying entries **1 - 10** of 11 in total

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Donor	Acceptor	Product	Reference
UDP-GalNAc	G93723GS		12966086
UDP-GalNAc	G61491DK		12966086
UDP-GalNAc	G96881BQ		12966086
UDP-GalNAc	G58161NS		12966086
UDP-GalNAc	G65889KE		12966086
UDP-GalNAc	G09546QO		12966086
UDP-GalNAc	G57321FI		12966086
UDP-GalNAc	G16579HJ		12966086
UDP-GalNAc	G61418DU		12966086
UDP-GalNAc	G71142DF		12966086

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	XP_575655	XM_575655
Mus musculus	NP_094510	NM_198884

KEGG BRITE Database

Orthology

K09656

Name

beta-1,4-N-acetylgalactosaminyltransferase 3 [EC:2.4.1.244]

References

12966086

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R07610	2.4.1.244	G88876JQ	G35429JB
R07611	2.4.1.244	G35429JB	G11960UF

Rhea

an N-acetyl-β-D-glucosaminyl derivative + UDP-N-acetyl-α-D-galactosamine

an N-acetyl-β-D-galactosaminyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + H⁺ + UDP

Enzyme

2.4.1.244

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 16 in total

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DO ID	Disease Name	Source
DOID:0060250	idiopathic scoliosis	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:1520	colon carcinoma	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET
DOID:219	colon cancer	DisGeNET
DOID:235	colonic benign neoplasm	DisGeNET
DOID:2394	ovarian cancer	DisGeNET
DOID:3112	papillary adenocarcinoma	DisGeNET
DOID:381	arthropathy	DisGeNET
DOID:3969	thyroid gland papillary carcinoma	DisGeNET

Ortholog

Displaying entries **1 - 10** of 71 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	553524	ZFIN:ZDB-GENE-030131-8615	DANRE14321
Danio rerio	561505	ZFIN:ZDB-GENE-060503-519
Esox lucius	105022210		ESOLU56846
Salmo trutta	115196693		SALTR13359
Gadus morhua	115551233		GADMO59399
Poecilia reticulata	103466673		POERE28865
Oreochromis niloticus	100709042		ORENI69279
Astatotilapia calliptera	113026852		ASTCA38429
Sparus aurata	115586673		SPAAU44278
Xenopus laevis	108704576	Xenbase:XB-GENE-6488633

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024