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phosphoglycolate phosphatase

Summary

Gene Symbol

PGP

Organism

Homo sapiens (human)

External Links

NCBI Gene

283871

HGNC

8909

KEGG Gene ID

hsa:283871

PubChem

283871

Alliance of Genome Resources

HGNC:8909

Annotation

Keyword

Carbohydrate metabolism
Magnesium
Metal-binding
Protein phosphatase
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
A6NDG6	Aspartate-based ubiquitous Mg(2+)-dependent phosphatase Phosphoglycolate phosphatase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
negative regulation of gluconeogenesis	IMP	26755581
glycerophospholipid metabolic process	IDA	26755581
glycerol biosynthetic process	IDA	26755581

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

alditol metabolic process [inference]

glycerol metabolic process [inference]

glycerol biosynthetic process

alditol biosynthetic process [inference]

glycerol biosynthetic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process [inference]

glycerol biosynthetic process

alditol biosynthetic process [inference]

glycerol biosynthetic process

polyol biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

alditol metabolic process [inference]

glycerol metabolic process [inference]

glycerol biosynthetic process

alditol biosynthetic process [inference]

glycerol biosynthetic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process [inference]

glycerol biosynthetic process

alditol biosynthetic process [inference]

glycerol biosynthetic process

polyol biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis [inference]

negative regulation of gluconeogenesis

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of carbohydrate metabolic process [inference]

negative regulation of gluconeogenesis

negative regulation of small molecule metabolic process [inference]

negative regulation of gluconeogenesis

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

regulation of small molecule metabolic process [inference]

regulation of glucose metabolic process [inference]

regulation of gluconeogenesis [inference]

negative regulation of gluconeogenesis

negative regulation of small molecule metabolic process [inference]

negative regulation of gluconeogenesis

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process [inference]

regulation of gluconeogenesis [inference]

negative regulation of gluconeogenesis

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis [inference]

negative regulation of gluconeogenesis

negative regulation of carbohydrate metabolic process [inference]

negative regulation of gluconeogenesis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of carbohydrate metabolic process [inference]

negative regulation of gluconeogenesis

negative regulation of small molecule metabolic process [inference]

negative regulation of gluconeogenesis

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

Displaying 1 entry
GO Term	Evidence Code	PMID
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
ADP phosphatase activity	IEA
glycerol-3-phosphatase activity	IBA IDA	26755581
glycerol-1-phosphatase activity	IEA
magnesium ion binding	ISS
protein tyrosine phosphatase activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

glycerol-1-phosphatase activity

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

nucleoside diphosphate phosphatase activity [inference]

ADP phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000184207

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K19269

Name

phosphoglycolate phosphatase [EC:3.1.3.18 3.1.3.48]

References

17478634

Rhea

H₂O + sn-glycerol 1-phosphate

glycerol + phosphate

Enzyme

3.1.3.21

PMID

H₂O

phosphate

Enzyme

3.1.3.48

PMID

H₂O + sn-glycerol 3-phosphate

glycerol + phosphate

Enzyme

3.1.3.21

Disease

Disease Ontology

Displaying entries **1 - 10** of **130** in total

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DO ID	Disease Name	Source
DOID:0014667	disease of metabolism	DisGeNET
DOID:0050589	inflammatory bowel disease	DisGeNET
DOID:0050635	alternating hemiplegia of childhood	DisGeNET
DOID:0050697	chorioamnionitis	DisGeNET
DOID:0050759	myotonic dystrophy type 2	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0050908	myelodysplastic syndrome	DisGeNET
DOID:0060058	lymphoma	DisGeNET
DOID:0060891	Parkinson's disease 19A	DisGeNET
DOID:0060895	Parkinson's disease 4	DisGeNET

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	178963	WB:WBGene00019604
Caenorhabditis elegans	178964	WB:WBGene00016892
Caenorhabditis elegans	178965	WB:WBGene00018424
Caenorhabditis elegans	183469	WB:WBGene00016664
Drosophila melanogaster	37541	FB:FBgn0034713
Drosophila melanogaster	38358	FB:FBgn0052487
Drosophila melanogaster	39985	FB:FBgn0036759
Drosophila melanogaster	39986	FB:FBgn0036760
Drosophila melanogaster	326220	FB:FBgn0052488
Callorhinchus milii	103178671		CALMI15953

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.0.0

Last updated: August 19, 2024