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phosphoglycolate phosphatase

Summary

Gene Symbol

PGP

Organism

Homo sapiens (human)

External Links

NCBI Gene

283871

HGNC

8909

KEGG Gene ID

hsa:283871

PubChem

283871

Alliance of Genome Resources

HGNC:8909

Annotation

Keyword

Carbohydrate metabolism
Magnesium
Metal-binding
Protein phosphatase
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
A6NDG6	Aspartate-based ubiquitous Mg(2+)-dependent phosphatase Phosphoglycolate phosphatase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
negative regulation of gluconeogenesis	IMP	26755581
glycerophospholipid metabolic process	IDA	26755581
glycerol biosynthetic process	IDA	26755581

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

alditol metabolic process [inference]

glycerol metabolic process [inference]

glycerol biosynthetic process

alditol biosynthetic process [inference]

glycerol biosynthetic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process [inference]

glycerol biosynthetic process

alditol biosynthetic process [inference]

glycerol biosynthetic process

polyol biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

alditol metabolic process [inference]

glycerol metabolic process [inference]

glycerol biosynthetic process

alditol biosynthetic process [inference]

glycerol biosynthetic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process [inference]

glycerol biosynthetic process

alditol biosynthetic process [inference]

glycerol biosynthetic process

polyol biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

alditol biosynthetic process [inference]

glycerol biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis [inference]

negative regulation of gluconeogenesis

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of carbohydrate metabolic process [inference]

negative regulation of gluconeogenesis

negative regulation of small molecule metabolic process [inference]

negative regulation of gluconeogenesis

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

regulation of small molecule metabolic process [inference]

regulation of glucose metabolic process [inference]

regulation of gluconeogenesis [inference]

negative regulation of gluconeogenesis

negative regulation of small molecule metabolic process [inference]

negative regulation of gluconeogenesis

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process [inference]

regulation of gluconeogenesis [inference]

negative regulation of gluconeogenesis

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis [inference]

negative regulation of gluconeogenesis

negative regulation of carbohydrate metabolic process [inference]

negative regulation of gluconeogenesis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of carbohydrate metabolic process [inference]

negative regulation of gluconeogenesis

negative regulation of small molecule metabolic process [inference]

negative regulation of gluconeogenesis

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

Displaying 1 entry
GO Term	Evidence Code	PMID
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
ADP phosphatase activity	IEA
glycerol-3-phosphatase activity	IBA IDA	26755581
glycerol-1-phosphatase activity	IEA
magnesium ion binding	ISS
protein tyrosine phosphatase activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

glycerol-1-phosphatase activity

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

nucleoside diphosphate phosphatase activity [inference]

ADP phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000184207

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K19269

Name

phosphoglycolate phosphatase [EC:3.1.3.18 3.1.3.48]

References

17478634

Rhea

H₂O + sn-glycerol 1-phosphate

glycerol + phosphate

Enzyme

3.1.3.21

PMID

H₂O

phosphate

Enzyme

3.1.3.48

PMID

H₂O + sn-glycerol 3-phosphate

glycerol + phosphate

Enzyme

3.1.3.21

Disease

Disease Ontology

Displaying entries **11 - 20** of **130** in total

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DO ID	Disease Name	Source
DOID:0060896	Parkinson's disease 23	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:0080221	obsolete major affective disorder 2	DisGeNET
DOID:0080348	Alzheimer's disease 1	DisGeNET
DOID:0110035	Alzheimer's disease 2	DisGeNET
DOID:0110037	Alzheimer's disease 5	DisGeNET
DOID:0110038	Alzheimer's disease 6	DisGeNET
DOID:0110039	Alzheimer's disease 7	DisGeNET
DOID:0110041	Alzheimer's disease 8	DisGeNET
DOID:0110043	Alzheimer's disease 10	DisGeNET

Ortholog

Displaying entries **71 - 74** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Cyprinus carpio carpio	122139206		CYPCA112811
Cyprinus carpio carpio	122146987		CYPCA112811
Nannospalax galili	103743742		NANGA13185
Strigops habroptila	115606307		STRHB10847

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Supported by JST NBDC Grant Number JPMJND2204

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Last updated: August 19, 2024