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melanin concentrating hormone receptor 1

Summary

Gene Symbol

MCHR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

2847

PubChem

2847

Alliance of Genome Resources

HGNC:4479

Annotation

Keyword

Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q99705	G-protein coupled receptor 24 MCH-1R SLC-1 Somatostatin receptor-like protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	TAS	10421367
generation of precursor metabolites and energy	TAS	10421367
neuropeptide signaling pathway	IBA
feeding behavior	TAS	10421367
cell surface receptor signaling pathway	IEA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

cellular metabolic process [inference]

generation of precursor metabolites and energy

multicellular organismal process [inference]

behavior [inference]

feeding behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

positive regulation of calcium ion transport

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport

positive regulation of biological process [inference]

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying **all 5** entries
GO Term	Evidence Code	PMID
non-motile cilium	ISS
plasma membrane	IBA TAS
neuron projection	IBA
ciliary membrane	IEA
cilium	IDA	28154160

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

ciliary membrane

plasma membrane region [inference]

cell projection membrane [inference]

ciliary membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

non-motile cilium

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

cilium

non-motile cilium

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
neuropeptide binding	IBA
hormone binding	IEA
signaling receptor binding	IEA
neuropeptide receptor activity	TAS	10860944
melanin-concentrating hormone receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding

amide binding [inference]

peptide binding [inference]

neuropeptide binding

hormone binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

neuropeptide receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled peptide receptor activity [inference]

neuropeptide receptor activity

melanin-concentrating hormone receptor activity

protein-hormone receptor activity [inference]

melanin-concentrating hormone receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
neuropeptide binding
neuropeptide signaling pathway

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:11981	morbid obesity	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 11 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Rattus norvegicus	83567		RGD:619841
Mus musculus	207911		MGI:2180756
Danio rerio	353180		ZFIN:ZDB-GENE-030502-5
Danio rerio	353181		ZFIN:ZDB-GENE-030502-4
Pan troglodytes	470220	9598_0:005361
Xenopus tropicalis	779692		Xenbase:XB-GENE-1018376
Pongo abelii	100438115	9601_0:00512f
Pan paniscus	100977443	9597_0:0053fa
Xenopus laevis	108702058		Xenbase:XB-GENE-17343609
Gorilla gorilla gorilla	109025507	9595_0:0055c3

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements