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WD repeat domain, phosphoinositide interacting 2

Summary

Gene Symbol

Wipi2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

288498

PubChem

288498

Alliance of Genome Resources

RGD:1359154

Annotation

Keyword

Autophagy
Lipid-binding
Membrane
Phosphoprotein
Reference proteome
Repeat
WD repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6AY57
A6K1P6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
protein localization to phagophore assembly site	IBA ISO ISS
autophagy of mitochondrion	IBA
protein lipidation involved in autophagosome assembly	IBA ISO
biological_process	ND
autophagy of peroxisome	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

catabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

autophagy of mitochondrion

macroautophagy [inference]

autophagy of peroxisome

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

autophagy of mitochondrion

macroautophagy [inference]

autophagy of peroxisome

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

macromolecule modification [inference]

protein modification process [inference]

protein lipidation [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

autophagy of mitochondrion

macroautophagy [inference]

autophagy of peroxisome

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to phagophore assembly site

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

process utilizing autophagic mechanism [inference]

autophagy [inference]

autophagy of mitochondrion

macroautophagy [inference]

autophagy of peroxisome

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

autophagy of mitochondrion

vacuole organization [inference]

autophagosome organization [inference]

autophagosome assembly

organelle assembly [inference]

autophagosome assembly

organelle disassembly [inference]

autophagy of mitochondrion

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

organelle disassembly [inference]

autophagy of mitochondrion

cellular component assembly [inference]

organelle assembly [inference]

autophagosome assembly

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to phagophore assembly site

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to phagophore assembly site

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
membrane	ISO
phagophore assembly site	ISO
phagophore assembly site membrane	IBA ISO ISS
protein-containing complex	IEA ISO
nucleoplasm	IEA ISO

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane

phagophore assembly site membrane

extrinsic component of membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

autophagosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

autophagosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
phosphatidylinositol-3,5-bisphosphate binding	IBA ISO ISS
phosphatidylinositol-3-phosphate binding	IBA ISO ISS
phosphatidylinositol-5-phosphate binding	ISO

GO Hierarchy

molecular function

binding [inference]

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-3,5-bisphosphate binding

ion binding [inference]

anion binding [inference]

phosphatidylinositol-3,5-bisphosphate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

WD repeat domain phosphoinositide-interacting protein 2

Functional Category

G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 5** entries
Gene Ontology
lipid binding
nucleophagy
phosphatidylinositol-3,5-bisphosphate binding
phosphatidylinositol-3-phosphate binding
protein localization to phagophore assembly site

Displaying **all 4** entries
InterPro
PROPPIN
WD40 repeat
WD40-repeat-containing domain superfamily
WD40/YVTN repeat-like-containing domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:12858	Huntington's disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **111** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	26100		HGNC:32225	HUMAN87700
Drosophila melanogaster	35396		FB:FBgn0032935
Drosophila melanogaster	38913		FB:FBgn0035850
Mus musculus	74781	10090_1:001a6b	MGI:1923831	MOUSE46979
Caenorhabditis elegans	179246		WB:WBGene00018294
Danio rerio	437002		ZFIN:ZDB-GENE-040718-488	DANRE31442
Bos taurus	512685			BOVIN21014
Canis lupus familiaris	608721			CANLF16304
Macaca mulatta	702966			MACMU32534
Pan troglodytes	737922			PANTR39635